公开(公告)号：US20220233689A1

公开(公告)日：2022-07-28

申请号：US17562958

申请日：2021-12-27

申请人： Bristol-Myers Squibb Company ,  Halozyme, Inc.

发明人： Masano Huang ,  Thomas Arthur Haby ,  Mehrnaz KHOSSRAVI ,  Scott Aaron HART ,  Rao Venkatramana MANTRI ,  Heather Elizabeth VEZINA ,  Amit ROY ,  Bindu Purnima MURTHY ,  Urvi Ashish ARAS ,  Kinjal SANGHAVI ,  Xiaochen ZHAO ,  Akintunde BELLO

IPC分类号： A61K39/395 ,  A61K38/47 ,  A61K9/00 ,  A61K47/26 ,  A61K47/22 ,  A61K47/18

摘要： The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.