公开(公告)号：US12104185B2

公开(公告)日：2024-10-01

申请号：US18599428

申请日：2024-03-08

申请人： Halozyme, Inc.

发明人： Ge Wei ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K9/00 ,  A61K38/00 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K9/0019 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34 ,  C12Y302/01035 ,  A61K38/00 ,  C07K2319/30 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  A61K38/28 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US12037618B2

公开(公告)日：2024-07-16

申请号：US17327586

申请日：2021-05-21

申请人： HALOZYME, INC.

发明人： Ge Wei ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K9/00 ,  A61K38/00 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K9/0019 ,  A61K38/28 ,  A61K38/47 ,  A61K45/06 ,  A61K47/10 ,  A61P35/00 ,  C07K14/47 ,  C12Q1/34 ,  C12Y302/01035 ,  A61K38/00 ,  C07K2319/30 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  A61K38/28 ,  A61K2300/00 ,  A61K38/47 ,  A61K2300/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US20240011008A1

公开(公告)日：2024-01-11

申请号：US18338189

申请日：2023-06-20

申请人： HALOZYME,INC.

发明人： Ge WEI ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  A61K9/00 ,  A61K47/10 ,  C12Q1/34 ,  A61P35/00 ,  C07K14/47

CPC分类号： C12N9/2474 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  C12Y302/01035 ,  A61K9/0019 ,  A61K47/10 ,  C12Q1/34 ,  A61P35/00 ,  C07K14/47 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  C07K2319/30 ,  A61K38/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US20230321203A1

公开(公告)日：2023-10-12

申请号：US18339995

申请日：2023-06-22

申请人： HALOZYME, INC.

发明人： Louis Bookbinder ,  Anirban Kundu ,  Gregory I. Frost

IPC分类号： A61K38/47 ,  C12N9/26 ,  A61K9/00 ,  A61K39/395

CPC分类号： A61K38/47 ,  C12Y302/01035 ,  C12N9/2474 ,  A61K9/0048 ,  A61K39/395 ,  Y02A50/30 ,  A61K38/00

摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration for in vitro fertilization, as well as administration of molecules, or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.

公开(公告)号：US20230295593A1

公开(公告)日：2023-09-21

申请号：US18068218

申请日：2022-12-19

申请人： HALOZYME, INC.

发明人： Ge WEI ,  H. Michael Shepard ,  Qiping Zhao ,  Robert James Connor

IPC分类号： C12N9/26 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  A61K9/00 ,  A61K47/10 ,  C12Q1/34

CPC分类号： C12N9/2474 ,  A61K38/47 ,  A61K38/28 ,  A61K45/06 ,  C12Y302/01035 ,  A61K9/0019 ,  A61K47/10 ,  C12Q1/34 ,  G01N2333/926 ,  G01N2333/928 ,  Y02A50/30 ,  A61K38/00

摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

公开(公告)号：US11723959B2

公开(公告)日：2023-08-15

申请号：US17062425

申请日：2020-10-02

申请人： HALOZYME, INC.

发明人： Louis H. Bookbinder ,  Anirban Kundu ,  Gregory I. Frost

IPC分类号： A61K38/47 ,  C12N9/26 ,  A61K9/00 ,  A61K39/395 ,  A61K38/00 ,  A61K39/00

CPC分类号： A61K38/47 ,  A61K9/0048 ,  A61K39/395 ,  C12N9/2474 ,  C12Y302/01035 ,  A61K38/00 ,  A61K2039/505 ,  Y02A50/30

摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration for in vitro fertilization, as well as administration of molecules, or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.

公开(公告)号：US11584923B2

公开(公告)日：2023-02-21

申请号：US15940803

申请日：2018-03-29

申请人： Halozyme, Inc.

发明人： Christopher D. Thanos ,  Lin Wang ,  H. Michael Shepard

IPC分类号： C12N9/78 ,  A61K38/48 ,  A61K38/00

摘要： Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.

公开(公告)号：US20210023184A1

公开(公告)日：2021-01-28

申请号：US17062425

申请日：2020-10-02

申请人： HALOZYME, INC.

发明人： Louis H. Bookbinder ,  Anirban Kundu ,  Gregory I. Frost

IPC分类号： A61K38/47 ,  C12N9/26 ,  A61K9/00 ,  A61K39/395

摘要： Provided are soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration for in vitro fertilization, as well as administration of molecules, or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino-terminal leader peptides that enhance secretion of sHASEGP. Sialated and pegylated forms of the sHASEGPs also are provided. Methods of treatment by administering sHASEGPs and modified forms thereof also are provided.

公开(公告)号：US10137104B2

公开(公告)日：2018-11-27

申请号：US15625177

申请日：2017-06-16

申请人： Halozyme, Inc.

发明人： Daniel C. Maneval ,  H. Michael Shepard ,  Curtis B. Thompson

IPC分类号： A61K31/337 ,  C12N9/26 ,  A61K9/00 ,  C12N9/06 ,  A61K31/56 ,  A61K38/47 ,  A61K31/37 ,  A61K31/42 ,  A61K31/573 ,  A61K31/706 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/60 ,  A61K47/56 ,  A61K47/64 ,  A61K47/48

摘要： Provided herein is combination cancer therapy effected by administering a polymer-conjugated hyaluronidase, and a tumor-targeted taxane, and optionally a further chemotherapeutic agent such as a nucleoside analog. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.

公开(公告)号：US20170166878A9

公开(公告)日：2017-06-15

申请号：US15094908

申请日：2016-04-08

申请人： Halozyme, Inc.

发明人： Christopher D. Thanos ,  Lin Wang ,  H. Michael Shepard

IPC分类号： C12N9/78 ,  A61K38/48

CPC分类号： C12N9/78 ,  A61K38/00 ,  A61K38/48 ,  C12Y305/04004

摘要： Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are methods and uses of the ADA2 proteins or conjugates for treating diseases and conditions, such as a tumor or cancer, and in particular any disease or condition associated with elevated adenosine or other associated marker.