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公开(公告)号：US20050240001A1
公开(公告)日：2005-10-27
申请号：US10510393
申请日：2003-03-31
申请人： Britta Evers , Ruehter Gerd , Eva Martin De La Nava , Mark Tebbe
发明人： Britta Evers , Ruehter Gerd , Eva Martin De La Nava , Mark Tebbe
CPC分类号： C07K5/0606 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06191
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译： 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法，其包括施用所述化合物。
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公开(公告)号：US20060167268A1
公开(公告)日：2006-07-27
申请号：US10510305
申请日：2003-03-31
申请人： Britta Evers , Ruehter Gerd , Eva Martin De La Nava , Mark Tebbe
发明人： Britta Evers , Ruehter Gerd , Eva Martin De La Nava , Mark Tebbe
IPC分类号： C07D275/02 , C07D207/24
CPC分类号： C07D275/02 , C07D275/06
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
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公开(公告)号：US07396846B2
公开(公告)日：2008-07-08
申请号：US10510393
申请日：2003-03-31
IPC分类号： A61K31/40 , A61K31/425 , C07D275/02 , C07D207/18
CPC分类号： C07K5/0606 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06191
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译： 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法，其包括施用所述化合物。
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公开(公告)号：US20050080110A1
公开(公告)日：2005-04-14
申请号：US10486867
申请日：2002-08-06
申请人： Daniel Sall , Jolie Bastian , Rushad Karanjawala , Cynthia Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Finley , Freddie Stevens , Vincent Rocco , Patrick Spinazze , John He , John Werner , William Trankle , Andrew Ratz
发明人： Daniel Sall , Jolie Bastian , Rushad Karanjawala , Cynthia Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Finley , Freddie Stevens , Vincent Rocco , Patrick Spinazze , John He , John Werner , William Trankle , Andrew Ratz
IPC分类号： A61K31/381 , A61K31/4045 , A61K31/41 , A61K31/4178 , A61K31/4196 , A61K31/42 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61P3/04 , A61P3/10 , A61P43/00 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D49/02 , C07D41/02 , C07D43/02
CPC分类号： C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity.
摘要翻译： 本发明涉及式（I）的β3肾上腺素能受体激动剂; 或其药学盐; 其能够增加细胞中的脂肪分解和能量消耗，因此可用于例如治疗2型糖尿病和/或肥胖症。
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公开(公告)号：US07125840B2
公开(公告)日：2006-10-24
申请号：US10380867
申请日：2001-10-09
申请人： Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
发明人： Jeffrey Alan Dodge , Britta Evers , Louis Nickolaus Jungheim , Brian Stephen Muehl , Gerd Ruehter , Kenneth Jeff Thrasher
IPC分类号： A01N37/18
CPC分类号： C07D275/06 , A61K31/4015 , A61K31/4025 , A61K31/404 , A61K31/425 , C07D209/54 , C07D401/10 , C07D409/04 , C07D409/10 , C07D417/04 , C07D417/06 , C07D417/10
摘要： This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.
摘要翻译： 本发明涉及可用于调节哺乳动物内源性生长激素水平的新化合物。 本发明还涉及用于合成所述化合物的新中间体，以及在这些合成中使用的新方法。 还包括治疗哺乳动物的方法，其包括施用所述化合物。
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公开(公告)号：US06730792B2
公开(公告)日：2004-05-04
申请号：US10311112
申请日：2002-12-13
申请人： Britta Evers , Cynthia Darshini Jesudason , Rushad Eruch Karanjawala , David Michael Remick , Daniel Jon Sall , Miles Goodman Siegel , Wolfgang Stenzel , Russell Dean Stucky , John Arnold Werner
发明人： Britta Evers , Cynthia Darshini Jesudason , Rushad Eruch Karanjawala , David Michael Remick , Daniel Jon Sall , Miles Goodman Siegel , Wolfgang Stenzel , Russell Dean Stucky , John Arnold Werner
IPC分类号： C07D40104
CPC分类号： C07D207/333 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/2054 , C07D213/30 , C07D213/82 , C07D213/84 , C07D261/08 , C07D277/24 , C07D333/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a &bgr;3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and/or obesity. The compound can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compound can be used to reduced neurogenic inflammation or as an antidepressant agent. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.
摘要翻译： 本发明涉及式（I）的β3肾上腺素能受体激动剂或其药用盐，其能够增加细胞中的脂肪分解和能量消耗，因此可用于治疗II型糖尿病和/或肥胖症。 该化合物也可用于降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠蠕动。 此外，该化合物可用于减少神经源性炎症或作为抗抑郁剂。 还公开了使用该化合物治疗糖尿病和肥胖以及降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠蠕动的组合物和方法。
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公开(公告)号：US07208505B2
公开(公告)日：2007-04-24
申请号：US10486867
申请日：2002-08-06
申请人： Daniel Jon Sall , Jolie Anne Bastian , Rushad Eruch Karanjawala , Cynthia Darshini Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
发明人： Daniel Jon Sall , Jolie Anne Bastian , Rushad Eruch Karanjawala , Cynthia Darshini Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
IPC分类号： C07D209/14 , C07D213/64 , A61K31/404 , A61K31/422 , A61K31/444
CPC分类号： C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity
摘要翻译： 本发明涉及式（I）的β3肾上腺素能受体激动剂; 或其药学盐; 其能够增加细胞中的脂肪分解和能量消耗，因此可用于例如治疗2型糖尿病和/或肥胖症
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