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公开(公告)号：US07208505B2
公开(公告)日：2007-04-24
申请号：US10486867
申请日：2002-08-06
申请人： Daniel Jon Sall , Jolie Anne Bastian , Rushad Eruch Karanjawala , Cynthia Darshini Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
发明人： Daniel Jon Sall , Jolie Anne Bastian , Rushad Eruch Karanjawala , Cynthia Darshini Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
IPC分类号： C07D209/14 , C07D213/64 , A61K31/404 , A61K31/422 , A61K31/444
CPC分类号： C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity
摘要翻译： 本发明涉及式（I）的β3肾上腺素能受体激动剂; 或其药学盐; 其能够增加细胞中的脂肪分解和能量消耗，因此可用于例如治疗2型糖尿病和/或肥胖症
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公开(公告)号：US07087635B2
公开(公告)日：2006-08-08
申请号：US11082106
申请日：2005-03-16
申请人： Daniel Jon Sall , Jolie Anne Bastian , Cynthia Darshini Jesudason , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz , Theo Schotten , Gerd Reuhter
发明人： Daniel Jon Sall , Jolie Anne Bastian , Cynthia Darshini Jesudason , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz , Theo Schotten , Gerd Reuhter
IPC分类号： A61K31/40 , A61K31/38 , C07D209/54 , C07D317/08 , C07D409/00
CPC分类号： C07D231/12 , C07D209/34 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/14
摘要： The present invention relates to a β3 adrenergic receptor agonist of formula I: or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity.
摘要翻译： 本发明涉及式I的β3肾上腺素能受体激动剂：或其药用盐; 其能够增加细胞中的脂肪分解和能量消耗，因此可用于治疗2型糖尿病和/或肥胖症。
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公开(公告)号：US06911463B2
公开(公告)日：2005-06-28
申请号：US10486508
申请日：2002-08-06
申请人： Daniel Jon Sall , Jolie Anne Bastian , Cynthia Darshini Jesudason , Theo Schotten , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
发明人： Daniel Jon Sall , Jolie Anne Bastian , Cynthia Darshini Jesudason , Theo Schotten , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
IPC分类号： A01N41/12 , A61K31/4045 , A61K31/4178 , A61K31/4196 , A61K31/427 , A61K31/4439 , A61K31/497 , A61P3/04 , A61P3/10 , C07D209/34 , C07D209/96 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/14 , C07D521/00 , A61K31/4035 , A61K31/425 , C07D209/44 , C07D209/54
CPC分类号： C07D231/12 , C07D209/34 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/14
摘要： The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type 2 diabetes and/or obesity.
摘要翻译： 本发明涉及式（I）的β3肾上腺素能受体激动剂; 或其药学盐; 其能够增加细胞中的脂肪分解和能量消耗，因此可用于治疗2型糖尿病和/或肥胖症。
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公开(公告)号：US06730792B2
公开(公告)日：2004-05-04
申请号：US10311112
申请日：2002-12-13
申请人： Britta Evers , Cynthia Darshini Jesudason , Rushad Eruch Karanjawala , David Michael Remick , Daniel Jon Sall , Miles Goodman Siegel , Wolfgang Stenzel , Russell Dean Stucky , John Arnold Werner
发明人： Britta Evers , Cynthia Darshini Jesudason , Rushad Eruch Karanjawala , David Michael Remick , Daniel Jon Sall , Miles Goodman Siegel , Wolfgang Stenzel , Russell Dean Stucky , John Arnold Werner
IPC分类号： C07D40104
CPC分类号： C07D207/333 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/0095 , A61K9/02 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/12 , A61K9/2054 , C07D213/30 , C07D213/82 , C07D213/84 , C07D261/08 , C07D277/24 , C07D333/16 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention relates to a &bgr;3 adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof, which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II diabetes and/or obesity. The compound can also be used to lower triglyceride levels and cholesterol levels or raise high density lipoprotein levels or to decrease gut motility. In addition, the compound can be used to reduced neurogenic inflammation or as an antidepressant agent. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for decreasing gut motility are also disclosed.
摘要翻译： 本发明涉及式（I）的β3肾上腺素能受体激动剂或其药用盐，其能够增加细胞中的脂肪分解和能量消耗，因此可用于治疗II型糖尿病和/或肥胖症。 该化合物也可用于降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠蠕动。 此外，该化合物可用于减少神经源性炎症或作为抗抑郁剂。 还公开了使用该化合物治疗糖尿病和肥胖以及降低甘油三酯水平和胆固醇水平或提高高密度脂蛋白水平或降低肠蠕动的组合物和方法。
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公开(公告)号：US07122680B2
公开(公告)日：2006-10-17
申请号：US10970194
申请日：2004-10-21
IPC分类号： C07D209/04 , C07D209/32 , C07D401/12 , C07D237/02 , A61K31/44
CPC分类号： C07D401/12 , C07D209/34 , C07D209/96 , C07D403/12 , C07D405/04 , C07D405/12
摘要： The present invention relates to a β3 adrenergic receptor agonist of formula I: or a pharmaceutical salt thereof; which is useful for treating Type II diabetes and/or obesity.
摘要翻译： 本发明涉及式I的β3 N 3肾上腺素能受体激动剂：或其药用盐; 其可用于治疗II型糖尿病和/或肥胖症。
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公开(公告)号：US06825220B2
公开(公告)日：2004-11-30
申请号：US10399206
申请日：2003-04-11
IPC分类号： A61K3144
CPC分类号： C07D401/12 , C07D209/34 , C07D209/96 , C07D403/12 , C07D405/04 , C07D405/12
摘要： The present invention relates to a &bgr;;3 adrenergic receptor agonist of formula I: (1); or a pharmaceutical salt thereof; which is useful for treating Type II diabetes and/or obesity.
摘要翻译： 本发明涉及式I的β3肾上腺素能受体激动剂：（1）; 或其药学盐; 其可用于治疗II型糖尿病和/或肥胖症。
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公开(公告)号：US06426417B1
公开(公告)日：2002-07-30
申请号：US09601707
申请日：2000-08-02
IPC分类号： C07D47102
CPC分类号： C07D471/04 , C07D333/38 , Y02P20/55
摘要： The present invention concerns intermediates, and processes directed to and from those intermediates, to a series of pyrimidine derivatives of formula (V), which are intermediates to useful antifolate compounds or are themselves useful antifolate compounds.
摘要翻译： 本发明涉及涉及中间体和从这些中间体引入的一系列式（Ⅴ）嘧啶衍生物的方法，它们是有用的抗叶酸化合物的中间体，或本身是有用的抗叶酸化合物。
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公开(公告)号：US6114327A
公开(公告)日：2000-09-05
申请号：US425093
申请日：1999-10-22
申请人： Steven Eugene Dunlap , Louis Nickolaus Jungheim , Mark Joseph Tebbe , Gilbert Thomas Voy , John Arnold Werner
发明人： Steven Eugene Dunlap , Louis Nickolaus Jungheim , Mark Joseph Tebbe , Gilbert Thomas Voy , John Arnold Werner
IPC分类号： A61K31/4168 , A61P31/12 , A61P31/16 , C07D235/30 , A61K31/4184 , A61K31/5377 , A61K31/541 , C07D417/04
CPC分类号： C07D235/30
摘要： The present application provides a series of benzimidazole compounds of formula I: ##STR1## which inhibit the growth of picornaviruses, such as rhinoviruses (bovine and human), enteroviruses such as polioviruses, coxsackieviruses of the A and B groups, or echo virus, cardioviruses such as encephalomyocarditis (EMC), apthoviruses such as foot and mouth disease virus, and flaviviruses such as hepatitis C virus and bovine viral diarrhea virus.Such compounds are also useful as intermediates for preparing additional benzimidazole antiviral compounds.
摘要翻译： 本申请提供了一系列式I的苯并咪唑化合物：其抑制微小核糖核酸病毒如牛病毒（牛和人），肠道病毒如脊髓灰质炎病毒，A组和B组的柯萨奇病毒，或回声病毒，心血管病毒如脑心肌炎 （EMC），口蹄疫病毒等角膜病毒，丙型肝炎病毒和牛病毒性腹泻病毒等黄病毒。 这样的化合物也可用作制备另外的苯并咪唑抗病毒化合物的中间体。
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