公开(公告)号：US20230036048A1

公开(公告)日：2023-02-02

申请号：US17887974

申请日：2022-08-15

Applicant: Brolis Sensor Technology, UAB ,  Universiteit Gent ,  IMEC VZW

Inventor： Augustinas Vizbaras ,  Kristijonas Vizbaras ,  Ieva Simonyte ,  Günther Roelkens

IPC: A61B5/1455 ,  G01N21/39

Abstract: A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AIGalnAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AIGal-nAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

公开(公告)号：US11177630B2

公开(公告)日：2021-11-16

申请号：US16965867

申请日：2019-01-31

Applicant: Brolis Sensor Technology, UAB

Inventor： Augustinas Vizbaras ,  Ieva Simonyte ,  Andreas De Groote ,  Kristijonas Vizbaras

IPC: G01J3/30 ,  H01S5/0687 ,  G01N21/39 ,  H01S5/14 ,  H01S5/30

Abstract: Methods for wavelength determination of widely tunable lasers and systems thereof may be implemented with solid-state laser based photonic systems based on photonic integrated circuit technology as well as discrete table top systems such as widely-tunable external cavity lasers and systems. The methods allow integrated wavelength control enabling immediate system wavelength calibration without the need for external wavelength monitoring instruments. Wavelength determination is achieved using a monolithic solid-state based optical cavity with a well-defined transmission or reflection function acting as a wavelength etalon. The solid-state etalon may be used with a wavelength shift tracking component, e.g., a non-balanced interferometer, to calibrate the entire laser emission tuning curve within one wavelength sweep. The method is particularly useful for integrated photonic systems based on Vernier-filter mechanism where the starting wavelength is not known a-priori, or for compact widely tunable external cavity lasers eliminating the need for calibration of wavelength via external instruments.

公开(公告)号：US11696707B2

公开(公告)日：2023-07-11

申请号：US17887974

申请日：2022-08-15

Applicant: Brolis Sensor Technology, UAB ,  Universiteit Gent ,  IMEC VZW

Inventor： Augustinas Vizbaras ,  Kristijonas Vizbaras ,  Ieva Simonyte ,  Günther Roelkens

IPC: A61B5/145 ,  A61B5/1455 ,  G01N21/39 ,  H01S5/026 ,  H01S5/125 ,  H01S5/20

CPC classification number: A61B5/1455 ,  G01N21/39 ,  A61B2562/0238 ,  H01S5/026 ,  H01S5/125 ,  H01S5/20

Abstract: A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AlGaInAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AlGa1-nAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

公开(公告)号：US20230047997A1

公开(公告)日：2023-02-16

申请号：US17887981

申请日：2022-08-15

Applicant: Brolis Sensor Technology, UAB ,  Universiteit Gent ,  IMEC VZW

Inventor： Augustinas Vizbaras ,  Kristijonas Vizbaras ,  Ieva Simonyte ,  Günther Roelkens

IPC: A61B5/1455 ,  G01N21/39

Abstract: A spectroscopic laser sensor based on hybrid lll-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a lll-V gain-chip, e.g., an AIGalnAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AIGalnAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

公开(公告)号：US11201453B2

公开(公告)日：2021-12-14

申请号：US17370668

申请日：2021-07-08

Applicant: Brolis Sensor Technology, UAB

Inventor： Augustinas Vizbaras ,  Ieva Simonyte ,  Andreas De Groote ,  Kristijonas Vizbaras

IPC: G01J3/30 ,  H01S5/0687 ,  G01N21/39 ,  H01S5/14 ,  H01S5/30

Abstract: Methods for wavelength determination of widely tunable lasers and systems thereof may be implemented with solid-state laser based photonic systems based on photonic integrated circuit technology as well as discrete table top systems such as widely-tunable external cavity lasers and systems. The methods allow integrated wavelength control enabling immediate system wavelength calibration without the need for external wavelength monitoring instruments. Wavelength determination is achieved using a monolithic solid-state based optical cavity with a well-defined transmission or reflection function acting as a wavelength etalon. The solid-state etalon may be used with a wavelength shift tracking component, e.g., a non-balanced interferometer, to calibrate the entire laser emission tuning curve within one wavelength sweep. The method is particularly useful for integrated photonic systems based on Vernier-filter mechanism where the starting wavelength is not known a-priori, or for compact widely tunable external cavity lasers eliminating the need for calibration of wavelength via external instruments.

公开(公告)号：US20210353183A1

公开(公告)日：2021-11-18

申请号：US17369517

申请日：2021-07-07

Applicant: Brolis Sensor Technology, UAB ,  Universiteit Gent ,  IMEC VZW

Inventor： Augustinas Vizbaras ,  Kristijonas Vizbaras ,  Ieva Simonyte ,  Günther Roelkens

IPC: A61B5/1455 ,  G01N21/39

Abstract: A spectroscopic laser sensor based on hybrid III-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a III-V gain-chip, e.g., an AlGaInAsSb/GaSb based gain-chip and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AlGaInAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

公开(公告)号：US11896373B2

公开(公告)日：2024-02-13

申请号：US16609355

申请日：2018-05-21

Applicant: Brolis Sensor Technology, UAB ,  Universiteit Gent ,  IMEC VZW

Inventor： Augustinas Vizbaras ,  Kristijonas Vizbaras ,  Ieva Simonyte ,  Günther Roelkens

IPC: A61B5/1455 ,  G01N21/39 ,  H01S5/026 ,  H01S5/125 ,  H01S5/20

CPC classification number: A61B5/1455 ,  G01N21/39 ,  A61B2562/0238 ,  H01S5/026 ,  H01S5/125 ,  H01S5/20

Abstract: A spectroscopic laser sensor based on hybrid lll-V/IV system-on-a-chip technology. The laser sensor is configured to either (i) be used with a fiber-optic probe connected to an intravenous/intra-arterial optical catheter for direct invasive blood analyte concentration level measurement or (ii) be used to measure blood analyte concentration level non-invasively through an optical interface attached, e.g., to the skin or fingernail bed of a human. The sensor includes a lll-V gain-chip, e.g., an AIGalnAsSb/GaSb based gain-chip, and a photonic integrated circuit, with laser wavelength filtering, laser wavelength tuning, laser wavelength monitoring, laser signal monitoring and signal output sections realized on a chip by combining IV-based semiconductor substrates and flip-chip AIGal-nAsSb/GaSb based photodetectors and embedded electronics for signal processing. Embodiments of the invention may be applied for real-time monitoring of critical blood analyte concentration levels such as lactates, urea, glucose, ammonia, albumin, etc.

公开(公告)号：US20230017186A1

公开(公告)日：2023-01-19

申请号：US17782239

申请日：2020-12-03

Applicant: Brolis Sensor Technology, UAB

Inventor： Ieva Simonyte ,  Augustinas Vizbaras ,  Tadas Buciunas ,  Arunas Miasojedovas ,  Stephan Heinz Sprengel

IPC: G01N21/39 ,  G01N21/27

Abstract: Techniques for acquiring and processing data in combination with a photonic sensor system-on-a-chip (SoC) (1) to provide real-time calibrated concentration levels of an analyte (e.g., a constituent molecule within a biological substance) are described. A raw signal (1300) to be analyzed is collected by the sensor chip (1) via diffuse reflectance or transmittance. Determination of the analyte concentration is based on, in part, Beer-Lambert principles and facilitated by applying (2240) scattering correction to the raw signal (1300) prior to decomposition and analysis thereof.

公开(公告)号：US20210351567A1

公开(公告)日：2021-11-11

申请号：US17370668

申请日：2021-07-08

Applicant: Brolis Sensor Technology, UAB

Inventor： Augustinas Vizbaras ,  Ieva Simonyte ,  Andreas De Groote ,  Kristijonas Vizbaras

IPC: H01S5/0687 ,  G01N21/39 ,  H01S5/14

Abstract: Methods for wavelength determination of widely tunable lasers and systems thereof may be implemented with solid-state laser based photonic systems based on photonic integrated circuit technology as well as discrete table top systems such as widely-tunable external cavity lasers and systems. The methods allow integrated wavelength control enabling immediate system wavelength calibration without the need for external wavelength monitoring instruments. Wavelength determination is achieved using a monolithic solid-state based optical cavity with a well-defined transmission or reflection function acting as a wavelength etalon. The solid-state etalon may be used with a wavelength shift tracking component, e.g., a non-balanced interferometer, to calibrate the entire laser emission tuning curve within one wavelength sweep. The method is particularly useful for integrated photonic systems based on Vernier-filter mechanism where the starting wavelength is not known a-priori, or for compact widely tunable external cavity lasers eliminating the need for calibration of wavelength via external instruments.

公开(公告)号：US20210021099A1

公开(公告)日：2021-01-21

申请号：US16965867

申请日：2019-01-31

Applicant: Brolis Sensor Technology, UAB

Inventor： Augustinas Vizbaras ,  Ieva Simonyte ,  Andreas De Groote ,  Kristijonas Vizbaras

IPC: H01S5/0687 ,  H01S5/14 ,  G01N21/39

Abstract: Methods for wavelength determination of widely tunable lasers and systems thereof may be implemented with solid-state laser based photonic systems based on photonic integrated circuit technology as well as discrete table top systems such as widely-tunable external cavity lasers and systems. The methods allow integrated wavelength control enabling immediate system wavelength calibration without the need for external wavelength monitoring instruments. Wavelength determination is achieved using a monolithic solid-state based optical cavity with a well-defined transmission or reflection function acting as a wavelength etalon. The solid-state etalon may be used with a wavelength shift tracking component, e.g., a non-balanced interferometer, to calibrate the entire laser emission tuning curve within one wavelength sweep. The method is particularly useful for integrated photonic systems based on Vernier-filter mechanism where the starting wavelength is not known a-priori, or for compact widely tunable external cavity lasers eliminating the need for calibration of wavelength via external instruments.