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    Focused libraries, functional profiling, laser SELEX, and DESELEX
    1.
    发明授权
    Focused libraries, functional profiling, laser SELEX, and DESELEX 有权
    专注图书馆，功能剖析，激光SELEX和DESELEX

    公开(公告)号：US08367627B2

    公开(公告)日：2013-02-05

    申请号：US11992125

    申请日：2006-09-15

    申请人： Bruce A. Sullenger ,  Juliana M. Layzer ,  Christopher P. Rusconi ,  Sabah Oney ,  Nanette L. S. Que-Gewirth

    发明人： Bruce A. Sullenger ,  Juliana M. Layzer ,  Christopher P. Rusconi ,  Sabah Oney ,  Nanette L. S. Que-Gewirth

    IPC分类号： C07H21/02

    CPC分类号： C12N15/1048 ,  C07K14/745 ,  C12N15/111 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/13

    摘要： Focused aptamer libraries are constructed in accordance with a proteome (i.e., complex mixture of native biomolecules). The libraries may be screened to identify one or more candidate aptamers with desired biological activities other than specific binding to a target. Aptamers which are selected or derivatives thereof may be used for those specific activities in biological systems. Any combination of deconvoluting a focused library (functional profiling), increasing frequencies of particular aptamers in a focused library (Laser SELEX), and decreasing frequencies of particular aptamers in a focused library (DeSELEX) may be performed prior to assaying biological activity.

    摘要翻译： 根据蛋白质组（即天然生物分子的复杂混合物）构建聚焦的适体文库。 可以筛选文库以鉴定具有除特异性结合靶标以外的所需生物活性的一种或多种候选适体。 选择的适体或其衍生物可用于生物系统中的那些特定活性。 在分析生物活性之前，可以进行解卷积聚焦库（功能分析），聚焦库（Laser SELEX）中特定适体的频率增加以及聚焦文库（DeSELEX）中特定适体的频率降低的任何组合。

    REVERSIBLE PLATELET INHIBITION
    7.
    发明申请
    REVERSIBLE PLATELET INHIBITION 审中-公开
    可逆板抑制

    公开(公告)号：US20110118187A1

    公开(公告)日：2011-05-19

    申请号：US12311943

    申请日：2007-10-19

    申请人： Bruce Sullenger ,  Shahid Nimjee ,  Sabah Oney ,  Nanette Que-Gewirth

    发明人： Bruce Sullenger ,  Shahid Nimjee ,  Sabah Oney ,  Nanette Que-Gewirth

    IPC分类号： A61K38/36 ,  C07H21/04 ,  A61K31/7088 ,  C07K14/00 ,  A61P7/00

    CPC分类号： C12N15/113 ,  A61K38/177 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/16

    摘要： The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.

    摘要翻译： 本发明一般涉及受体和血小板聚集，特别涉及使用结合并抑制受体（例如糖蛋白IIb / IIIa（gpIIb / IIIa））的活性的适体抑制血小板聚集的方法 ）以及适用于这种方法的适体。 本发明还涉及抗血小板剂的解毒剂以及使用这种解毒剂来逆转适体诱导的血小板抑制的方法。 本发明还涉及血管性血友病因子（VWF）抑制剂和解毒剂，以及其使用方法。