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    METHODS TO INCREASE PERMEABILITY OF CORNEAL EPITHELIUM AND DESTABILIZE STROMAL COLLAGEN FIBRIL NETWORK
    1.
    发明申请
    METHODS TO INCREASE PERMEABILITY OF CORNEAL EPITHELIUM AND DESTABILIZE STROMAL COLLAGEN FIBRIL NETWORK 审中-公开
    方法提高角膜上皮细胞的渗透性，并减少粘膜胶原纤维网络

    公开(公告)号：US20110086802A1

    公开(公告)日：2011-04-14

    申请号：US12934310

    申请日：2009-03-18

    申请人： Bruce Dewoolfson ,  Dale Devore

    发明人： Bruce Dewoolfson ,  Dale Devore

    IPC分类号： A61K38/39 ,  A61K31/365 ,  A61K31/194 ,  A61P27/02 ,  A61K38/17

    CPC分类号： A61K38/39 ,  A61K31/185 ,  A61K31/341 ,  A61K38/1709 ,  A61K39/39 ,  A61K45/06 ,  A61K2300/00

    摘要： Methods of increasing the permeability of corneal epithelium to facilitate the diffusion of agents into the collagen fibrillar network of the stroma are provided. Used in combination, these methods open the epithelium to facilitate diffusion of stabilization molecules into the stroma and dissociate bridging molecules from stromal collagen fibers, thereby priming the collagen fibrillar network for restabilization by stabilization molecules. These methods can be used to increase the effectiveness and longevity of non-invasive corneal reshaping, such as orthokeratology, for correcting myopia, hyperopia and astigmatism.

    摘要翻译： 提供了增加角膜上皮的渗透性以促进试剂扩散到基质的胶原原纤维网中的方法。 组合使用，这些方法打开上皮，以促进稳定分子扩散到基质中，并将桥接分子从基质胶原纤维解离，从而引发胶原纤维网络，以通过稳定分子进行再稳定化。 这些方法可用于增加非侵入性角膜重塑（如角膜矫正术）矫正近视，远视和散光的有效性和寿命。

    Implantation Compositions for Use in Tissue Augmentation
    2.
    发明申请
    Implantation Compositions for Use in Tissue Augmentation 审中-公开
    用于组织增强的植入组合物

    公开(公告)号：US20100041788A1

    公开(公告)日：2010-02-18

    申请号：US12521947

    申请日：2007-07-31

    申请人： Robert Voigts ,  Dale Devore

    发明人： Robert Voigts ,  Dale Devore

    IPC分类号： A61F2/00

    CPC分类号： A61K47/38 ,  A61K31/167 ,  A61K47/02 ,  A61K47/10 ,  A61L2/0023 ,  A61L27/20 ,  A61L27/50 ,  A61L2400/06 ,  A61L2430/34 ,  C08L1/286 ,  C08L1/26

    摘要： A composition of matter and method for preparation of a tissue augmentation material. A polysaccharide gel composition is prepared with rheological properties selected for a particular selected application. The method includes preparing a polymeric polysaccharide in a buffer to create a polymer solution or gel suspending properties in the gel and selecting a rheology profile for the desired tissue region.

    摘要翻译： 用于制备组织增强材料的物质组合物和方法。 制备具有针对特定选定应用选择的流变性质的多糖凝胶组合物。 该方法包括在缓冲液中制备聚合多糖以产生凝胶中的聚合物溶液或凝胶悬浮性质并选择所需组织区域的流变学特性。

    Chemical treatment of in vivo tissue to alter charge and net charge density characteristics
    3.
    发明申请
    Chemical treatment of in vivo tissue to alter charge and net charge density characteristics 审中-公开
    化学处理体内组织以改变电荷和净电荷密度特征

    公开(公告)号：US20050106270A1

    公开(公告)日：2005-05-19

    申请号：US10959740

    申请日：2004-10-06

    申请人： Dale Devore ,  Braden Devore

    发明人： Dale Devore ,  Braden Devore

    IPC分类号： A61K33/00

    CPC分类号： A61K33/00

    摘要： A method for treating animal tissue with acylation agents to alter the net charge and net charge density of the treated tissue for therapeutic applications is provided. The method involves applying an alkaline solution to the exposed tissue surface area. This results in deprotonation of ε-amino groups of lysine residues on the exposed tissue proteins so that the tissue proteins have a net charge. Then, an acylating agent is applied and the acylating agent reacts with the tissue protein to form a protein complex having an altered net charge. Acylating agents such as sulfonic acids, sulfonyl chlorides, and acid chlorides can be used. The method can be used to treat a wide variety of human tissues including the human cornea for correcting myopia. The method can also be used to treat skin tissue, so that there is an increase in dermal thickness and pliability. The method can be further used to treat articular cartilage.

    摘要翻译： 提供了一种用酰化剂处理动物组织以改变用于治疗应用的经处理组织的净电荷和净电荷密度的方法。 该方法包括向暴露的组织表面区域施加碱性溶液。 这导致在暴露的组织蛋白上赖氨酸残基的ε-氨基的去质子化，使得组织蛋白质具有净电荷。 然后，施加酰化剂，并且酰化剂与组织蛋白质反应形成具有改变的净电荷的蛋白质复合物。 可以使用酰化剂如磺酸，磺酰氯和酰氯。 该方法可用于治疗各种人体组织，包括用于矫正近视的人角膜。 该方法也可用于治疗皮肤组织，使真皮厚度和柔韧性增加。 该方法可以进一步用于治疗关节软骨。