公开(公告)号：US07348315B2

公开(公告)日：2008-03-25

申请号：US10396200

申请日：2003-03-25

申请人： Bruce T Liang ,  Kenneth A Jacobson

发明人： Bruce T Liang ,  Kenneth A Jacobson

IPC分类号： A61K31/70 ,  C07H19/20

CPC分类号： C07F9/65586 ,  C07F9/6561 ,  C07H19/20 ,  C07K14/705

摘要： Disclosed herein are methods of using an adenosine analog or derivative for treating heart failure, increasing cardiac muscle contractility, increasing cardiac diastolic relaxation, and increasing vasodilation. Exemplary adenosine analogs/derivatives include compounds of the following formula wherein L is CH or O, wherein when L is CH, t is 1 and when L is O, t is 0; R1 is halogen or —R6—(R7)p—R8; R2 is hydrogen, alkyl, cycloalkyl, cycloalkenyl, alkynyl, alkylthio, aminoalkylthio, halogen, or —R6—(R7)p—R8; R3 is H, halogen or —R6—(R7)p—R8; R4 is —OH or —SH; R5 is —OH or —R6—(R7)p—R8; R6is NH or S; R7is CH2; R8 is H, NH2, halogen, CN, CCH, cycloallkyl, having 3 to about 10 carbon atoms or aryl having 3 to about 20 carbon atoms; R9 is OH or acetamido; R10 and R11 are independently hydrogen or halogen; X, Y, and Z are independently N or CH; m is 0, 1, or 2; n is 0 or 1; q is 0 or 1 if L is CH, or if L is O, R3 is halogen or —R6—(R7)p—R8; q is 1 if L is O, R3 is H, halogen, or —R6—(R7)p—R8; provided that at least one of m, n, and q is 1; and p is 0 to 10.