公开(公告)号：US20190170670A1

公开(公告)日：2019-06-06

申请号：US15829068

申请日：2017-12-01

Applicant: Bruker AXS GmbH

Inventor： Roger D. DURST ,  Christoph OLLINGER

IPC: G01N23/223 ,  H01J35/06 ,  H01J35/22 ,  G21K1/06 ,  H05G1/04 ,  H05G1/30

CPC classification number: G01N23/223 ,  G21K1/06 ,  H01J35/06 ,  H01J35/08 ,  H01J35/22 ,  H01J2235/082 ,  H01J2235/086 ,  H05G1/04 ,  H05G1/30 ,  H05G2/003 ,  H05G2/005 ,  H05G2/006

Abstract: An X-ray source uses excitation of a liquid metal beam of ions or ionized droplets to produce an X-ray output with higher brightness than conventional sources. The beam may be accelerated from a liquid metal source using an extraction electrode. The source may have an emitter tip, and the acceleration of the liquid metal may include field emission from a Taylor cone. An electrostatic or electromagnetic focusing electrode may be used to reduce a cross-sectional diameter of the beam. The liquid metal beam has a relatively high velocity as it does not suffer from flow turbulence, thus allowing for a more energetic excitation and a correspondingly higher brightness. A beam dump may also be used to collect the liquid metal beam after excitation, and may be concave with no direct sight lines to either an electron beam cathode or to X-ray windows of an enclosure for the source.

公开(公告)号：US20220163431A1

公开(公告)日：2022-05-26

申请号：US17430798

申请日：2020-02-12

Applicant: Bruker AXS GmbH

Inventor： Christoph OLLINGER ,  Roger D. DURST

IPC: G01N1/36

Abstract: In a method of preparing a single molecule sample of a biological material for use in an imaging experiment, the single molecule sample is deposited on a graphene substrate using a method such as nanopipetting. Excess bulk fluid surrounding the molecule is then removed, for example, by mechanical blotting or controlled evaporation. An enclosing layer of graphene is then deposited and sealed to the graphene substrate so as to encapsulate the molecule. This sealing may include floating the enclosing layer in a water bath and moving it into contact with the graphene substrate. The molecule of interest may be deposited directly on the substrate, or a linker molecule may be first deposited to provide an attachment between the substrate and the molecule of interest.

公开(公告)号：US20200135424A1

公开(公告)日：2020-04-30

申请号：US16176639

申请日：2018-10-31

Applicant: Bruker AXS GmbH

Inventor： Roger D. DURST ,  Christoph OLLINGER

IPC: H01J37/09 ,  H01J37/26 ,  H01J37/20

Abstract: An electron diffraction imaging system for imaging the three-dimensional structure of a single target molecule of a sample uses an electron source that emits a beam of electrons toward the sample, and a two-dimensional detector that detects electrons diffracted by the sample and generates an output indicative of their spatial distribution. A sample support is transparent to electrons in a region in which the sample is located, and is rotatable and translatable in at least two perpendicular directions. The electron beam has an operating energy between 5 keV and 30 keV, and beam optics block highly divergent electrons to limit the beam diameter to no more than three times the size of the sample molecule and provide a lateral coherence length of at least 15 nm. An adjustment system adjusts the sample support position in response to the detector output to center the target molecule in the beam.

公开(公告)号：US20190057832A1

公开(公告)日：2019-02-21

申请号：US15679853

申请日：2017-08-17

Applicant: Bruker AXS, GmbH

Inventor： Roger D. DURST ,  Carsten MICHAELSEN ,  Paul RADCLIFFE ,  Jenss SCHMIDT-MAY

IPC: H01J35/08 ,  H01J35/10 ,  G03F7/36 ,  H01J35/12 ,  G03F7/16

Abstract: An analytical X-ray tube with an anode target material that emits characteristic X-rays in response to excitation by an electron beam may include any of several advantageous features. The target material is deposited on a diamond substrate layer, and a metal carbide intermediate layer may be provided between the target material and substrate that provides enhanced bonding therebetween. An interface layer may also be used that provides an acoustic impedance matching between the target material and the substrate. For a low thermal conductivity target material, a heat dissipation layer of a higher thermal conductivity material may also be included between the target material and substrate to enhance thermal transfer. The target material may have a thickness that corresponds to a maximum penetration depth of the electrons of the electron beam, and the structure may be such that a predetermined temperature range is maintained at the substrate interface.