公开(公告)号：US12040169B2

公开(公告)日：2024-07-16

申请号：US17237995

申请日：2021-04-22

申请人： Bruker Daltonics GmbH & Co. KG

发明人： Tobias Boskamp ,  Dennis Trede

IPC分类号： H01J49/00 ,  G01N27/623 ,  H01J49/16

CPC分类号： H01J49/0036 ,  G01N27/623 ,  H01J49/164

摘要： The invention relates to methods for processing ion-spectrometric measurement signal data which are recorded spatially resolved across a two-dimensional sample, comprising: —providing the measurement signal data which have a plurality of measurement signal histograms, where a histogram contains a measurement signal tuple with intensity dimension (J), mass dimension (m), and collision cross-section dimension (σ), or quantities derived therefrom; —specifying first and second selections of ionic species for the sample, whose presence in histograms is detectable and distinguishable using the collision cross-section dimension or proxy; —determining the spatially resolved content of ionic species from the first and second selections in histograms of the finite areas (Afin,x,y), and computing the various contents to form spatially resolved content scores (Gx,y); and—labeling the sample with the content scores (Gx,y). The invention also relates to methods for acquiring and processing ion-spectrometric measurement signal data, and ion mobility-mass spectrometers.

公开(公告)号：US11747343B2

公开(公告)日：2023-09-05

申请号：US17471473

申请日：2021-09-10

申请人： Bruker Daltonics GmbH & Co. KG

发明人： Tobias Boskamp

IPC分类号： G01N33/68 ,  G16B40/10 ,  H01J49/00

CPC分类号： G01N33/6848 ,  G16B40/10 ,  H01J49/0009 ,  H01J49/0036

摘要： The invention relates to a method to evaluate mass spectrometry data for the analysis of peptides from biological samples, particularly MALDI-TOF mass spectrometry data, comprising the steps of: providing expected mass defects; determining measured mass defects, i.e. the mass defects resulting from the mass spectrometry data; and comparing the measured mass defects with the expected mass defects.