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1.发明申请Novel form of irbesartan, processes for obtaining the said and pharmaceutical compositions containing it 有权厄贝沙坦的新型形式，获得所述药物的方法和含有它的药物组合物公开(公告)号：US20050032862A1
公开(公告)日：2005-02-10
申请号：US10937467
申请日：2004-09-09
申请人： Bruno Franc , Christian Hoff , San Kiang , Mark Lindrud , Olivier Monnier , Chenkou Wei
发明人： Bruno Franc , Christian Hoff , San Kiang , Mark Lindrud , Olivier Monnier , Chenkou Wei
IPC分类号： A61K31/4178 , A61P9/00 , A61P9/12 , A61P13/12 , A61P25/00 , A61P27/02 , A61P43/00 , C07D403/10 , A61K31/4188 , C07D43/02
CPC分类号： C07D403/10
摘要： The invention relates to a novel crystalline form of irbesartan, to pharmaceutical compositions containing it, to processes for preparing it, and to a method for treating cardiovascular diseases utilizing it.
摘要翻译： 本发明涉及厄贝沙坦的新型结晶形式，含有它的药物组合物，其制备方法以及利用其治疗心血管疾病的方法。
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2.发明授权Form of irbesartan, processes for obtaining the said and pharmaceutical compositions containing it 有权厄贝沙坦的形式，获得所述药物的方法和含有它的药物组合物公开(公告)号：US07008959B2
公开(公告)日：2006-03-07
申请号：US10937467
申请日：2004-09-09
申请人： Bruno Franc , Christian Hoff , San Kiang , Mark D. Lindrud , Olivier Monnier , Chenkou Wei
发明人： Bruno Franc , Christian Hoff , San Kiang , Mark D. Lindrud , Olivier Monnier , Chenkou Wei
IPC分类号： A61K31/415 , C07D403/10
CPC分类号： C07D403/10
摘要： The invention relates to a novel crystalline form of irbesartan to pharmaceutical compositions containing it, to processes for preparing it, and to a method for treating cardiovascular diseases utilizing it.
摘要翻译： 本发明涉及厄贝沙坦与含有它的药物组合物的新结晶形式，其制备方法以及利用其治疗心血管疾病的方法。
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3.发明授权Form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same 有权厄贝沙坦的形式，获得所述形式的方法和含有它们的药物组合物公开(公告)号：US06800761B1
公开(公告)日：2004-10-05
申请号：US09720017
申请日：2001-03-12
申请人： Bruno Franc , Christian Hoff , San Kiang , Mark D. Lindrud , Olivier Monnier , Chenkou Wei
发明人： Bruno Franc , Christian Hoff , San Kiang , Mark D. Lindrud , Olivier Monnier , Chenkou Wei
IPC分类号： C07D40310
CPC分类号： C07D403/10
摘要： The invention relates to a novel crystalline form of irbesartan, to pharmaceutical compositions containing it, to processes for preparing it, and to a method for treating cardiovascular diseases utilizing it.
摘要翻译： 本发明涉及厄贝沙坦的新型结晶形式，含有它的药物组合物，其制备方法以及利用其治疗心血管疾病的方法。
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4.发明授权
公开(公告)号：US5804192A
公开(公告)日：1998-09-08
申请号：US539463
申请日：1995-10-05
申请人： Bruno Franc , Christian Hoff
发明人： Bruno Franc , Christian Hoff
IPC分类号： A61K31/35 , A61K31/352 , A61K31/353 , A61K36/87 , C07D311/32 , C07D311/40 , C07D311/62 , A01N65/00 , A61K35/78 , A61K39/385 , B01D61/00
CPC分类号： C07D311/62 , C07D311/32 , C07D311/40
摘要： The invention relates to a process for obtaining procyanidol oligomers according to which: an appropriate plant is treated by means of an extractive mixture composed of water, of a water-miscible organic solvent capable of dissolving the procyanidol oligomers and of sodium chloride, the crude mixture of procyanidol oligomers obtained is purified by removal of the extractive mixture and extraction of the residue, the extractive mixture optionally being recycled in the stage of treatment of the plant, the procyanidol oligomers are recovered in a pure form by precipitation.
摘要翻译： 本发明涉及一种获得原花青素低聚物的方法，根据该方法，合适的植物通过由水，可溶解原花青素低聚物和氯化钠的水混溶性有机溶剂的萃取混合物，粗混合物 得到的原花青素低聚物通过除去萃取混合物和提取残余物进行纯化，萃取混合物任选地在植物处理阶段循环使用，原花青素低聚物以纯的形式通过沉淀回收。
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5.发明授权Device and method for calibrating a planishing roller device by means of an instrumented bar 有权通过仪表杆校准平面滚子装置的装置和方法公开(公告)号：US07584638B2
公开(公告)日：2009-09-08
申请号：US10548988
申请日：2004-03-03
申请人： Olivier Madelaine-Dupuich , Stéphane Rossi , Gilbert Petig , Philippe Wallendorf , Dominique Kircher , Fabrice Tondo , Eric Vasseur , Alain Fouratier , Jacques-Yves Bourgon , Christian Hoff
发明人： Olivier Madelaine-Dupuich , Stéphane Rossi , Gilbert Petig , Philippe Wallendorf , Dominique Kircher , Fabrice Tondo , Eric Vasseur , Alain Fouratier , Jacques-Yves Bourgon , Christian Hoff
CPC分类号： B21D1/02
摘要： A device for calibrating a multi-roll leveler for leveling a metal strip includes an assembly having two series of rolls, namely upper rolls and lower rolls which face each other so as to imbricate the rolls of one series into those of the other. The series of rolls are placed substantially parallel to each other and perpendicular to the run direction of the strip to be leveled. A rigid measurement bar of sufficient length is positioned in the leveling direction between the upper and lower rolls, extending over all the rolls, and having rigid protrusions integral with the bar reproducing, when they are placed plumb with the lower rolls, the action of the lower rolls and their mechanical properties. A thin metal plate rests on these protrusions and is fastened to one of them at around the middle of the bar and includes extensometers for measuring its elastic deformations.
摘要翻译： 用于校准用于使金属条调平的多辊矫直机的装置包括具有两个系列辊的组件，即上辊和下辊，它们彼此面对，以将一个系列的辊子覆盖到另一个的辊中。 一系列辊被放置成基本上彼此平行并垂直于待平整的条带的行进方向。 具有足够长度的刚性测量棒定位在上辊和下辊之间的调平方向上，在所有辊上延伸，并且当与下辊一起放置时，具有与杆再现成一体的刚性突起， 下辊及其机械性能。 薄金属板搁置在这些突起上，并被固定在其中一个围绕杆的中部，并且包括用于测量其弹性变形的引伸计。
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公开(公告)号：US08742077B2
公开(公告)日：2014-06-03
申请号：US13119326
申请日：2009-09-15
IPC分类号： C07H3/02
CPC分类号： C07H3/02 , C07D493/18
摘要： The invention relates to a method for preparing 1,6:2,3-dianhydro-â-D-mannopyranose and is characterized in that it includes a step of cyclizing the compound C, where R is an alykyl group and R′ is an activating agent, in an alcohol/alcoholate mixture under anhydrous conditions.
摘要翻译： 本发明涉及一种制备1,6：2,3-二脱水-D-甘露吡喃糖的方法，其特征在于它包括使化合物C环化的步骤，其中R是亚烷基，R'是活化的 试剂，在无水条件下的醇/醇化物混合物中。
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公开(公告)号：US20120022292A1
公开(公告)日：2012-01-26
申请号：US13128756
申请日：2009-11-10
申请人： Eric Garcia , Christian Hoff
发明人： Eric Garcia , Christian Hoff
IPC分类号： C07C249/12
CPC分类号： C07C249/14 , C07B2200/07 , C07C51/412 , C07C57/15 , C07C251/58
摘要： Method for preparing eplivanserin hemifumarate.
摘要翻译： 依普伐他汀半富马酸盐的制备方法。
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8.发明申请Device and method for calibrating a planishing roller device by means of an instrumented bar 有权通过仪表杆校准平面滚子装置的装置和方法公开(公告)号：US20070033976A1
公开(公告)日：2007-02-15
申请号：US10548988
申请日：2004-03-03
申请人： Olivier Madelaine-Dupuis , Stephane Rossi , Gilbert Petig , Philippe Wallendorf , Dominique Kircher , Fabrice Tondo , Eric Vasseur , Alain Fouratier , Jacques-Yves Bourgon , Christian Hoff
发明人： Olivier Madelaine-Dupuis , Stephane Rossi , Gilbert Petig , Philippe Wallendorf , Dominique Kircher , Fabrice Tondo , Eric Vasseur , Alain Fouratier , Jacques-Yves Bourgon , Christian Hoff
CPC分类号： B21D1/02
摘要： A device for calibrating a multi-roll leveler for leveling a metal strip includes an assembly having two series of rolls, namely upper rolls and lower rolls which face each other so as to imbricate the rolls of one series into those of the other. The series of rolls are placed substantially parallel to each other and perpendicular to the run direction of the strip to be leveled. A rigid measurement bar of sufficient length is positioned in the leveling direction between the upper and lower rolls, extending over all the rolls, and having rigid protrusions integral with the bar reproducing, when they are placed plumb with the lower rolls, the action of the lower rolls and their mechanical properties. A thin metal plate rests on these protrusions and is fastened to one of them at around the middle of the bar and includes extensometers for measuring its elastic deformations.
摘要翻译： 用于校准用于使金属条平整的多辊矫直机的装置包括具有两个系列辊的组件，即上辊和下辊，它们彼此面对，以将一个系列的辊子覆盖到另一个的辊中。 一系列辊被放置成基本上彼此平行并垂直于待平整的条带的行进方向。 具有足够长度的刚性测量棒定位在上辊和下辊之间的调平方向上，在所有辊上延伸，并且当与下辊一起放置时，具有与杆再现成一体的刚性突起， 下辊及其机械性能。 薄金属板搁置在这些突起上，并被固定在其中一个围绕杆的中部，并且包括用于测量其弹性变形的引伸计。
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公开(公告)号：US20110213141A1
公开(公告)日：2011-09-01
申请号：US13119326
申请日：2009-09-15
IPC分类号： C07H3/02
CPC分类号： C07H3/02 , C07D493/18
摘要： The invention relates to a method for preparing 1,6:2,3-dianhydro-â-D-mannopyranose and is characterized in that it includes a step of cyclizing the compound C, where R is an alykyl group and R′ is an activating agent, in an alcohol/alcoholate mixture under anhydrous conditions.
摘要翻译： 本发明涉及一种制备1,6：2,3-二脱水-D-甘露吡喃糖的方法，其特征在于它包括使化合物C环化的步骤，其中R是亚烷基，R'是活化的 试剂，在无水条件下的醇/醇化物混合物中。
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