公开(公告)号：US20070275080A1

公开(公告)日：2007-11-29

申请号：US10577785

申请日：2004-10-29

申请人： Bryan Laulicht ,  Sasha Bakhru

发明人： Bryan Laulicht ,  Sasha Bakhru

IPC分类号： A61K9/14 ,  B41J2/01

CPC分类号： B01J13/14 ,  B01J13/08

摘要： The present invention relates to the fields of controlled release of drugs, proteins, nucleic acids, and other pharmaceuticals. It also relates to delivery systems for these agents and other compounds. The invention also relates to stable encapsulation of cells and molecules. The invention provides a population of microstructures comprising a permeable polymer shell, wherein the standard variance in the volume of the microstructures is usually less than or equal to 20%, preferably 10%, of the mean, and wherein the diffusion characteristics of the polymer shell vary within the population of microstructures. It also provides for an apparatus and a method of forming a population of microstructures, which method for making microstructures by introducing drops of a polymer solution into a receiving solution under conditions that permit cross-linking of the polymer in the receiving solution. Microstructures of calcium-cross-linked alginate with a chitosin capsule are disclosed.

摘要翻译： 本发明涉及药物，蛋白质，核酸和其他药物的控制释放领域。 它还涉及这些试剂和其它化合物的递送系统。 本发明还涉及细胞和分子的稳定包封。 本发明提供了包含可渗透聚合物壳的微观组织群，其中微结构体积的标准差异通常小于或等于平均值​​的20％，优选10％，并且其中聚合物壳的扩散特性 在微观结构的群体内变化。 它还提供了一种形成微观结构群的装置和方法，该方法通过在允许聚合物在接收溶液中交联的条件下将聚合物溶液的液滴引入接收溶液来制备微结构。 公开了钙交联藻酸盐与壳聚糖胶囊的微结构。

公开(公告)号：US20140120162A1

公开(公告)日：2014-05-01

申请号：US14124040

申请日：2012-06-06

申请人： Edith Mathiowitz ,  Solomon S. Steiner ,  Bryan E. Laulicht ,  Sasha Bakhru

发明人： Edith Mathiowitz ,  Solomon S. Steiner ,  Bryan E. Laulicht ,  Sasha Bakhru

IPC分类号： A61K47/34 ,  A61K47/32

CPC分类号： A61K47/34 ,  A61K9/4858 ,  A61K47/32

摘要： Compositions containing one or more active agents, one or more bioadhesives elements, and one or more charge masking agents are described herein. In some embodiments, the one or more active agents are biomolecules or macromolecules, such as polysaccharides, proteins, peptides, or nucleic acids, which are charged at physiological pH. The one or more charge masking agents are selected based on the nature of the charge on the active agent. The compositions may also contain one or more controlled release materials, such as extended or sustained release materials or delayed release materials, in order to modify release of the active agent.

摘要翻译： 本文描述了包含一种或多种活性剂，一种或多种生物粘合剂元件和一种或多种电荷掩蔽剂的组合物。 在一些实施方案中，一种或多种活性剂是在生理pH下加入的生物分子或大分子，例如多糖，蛋白质，肽或核酸。 基于活性剂上的电荷的性质来选择一种或多种电荷掩蔽剂。 为了改变活性剂的释放，组合物还可以含有一种或多种受控释放材料，例如延长或持续释放材料或延迟释放材料。

公开(公告)号：US20110221083A1

公开(公告)日：2011-09-15

申请号：US13047426

申请日：2011-03-14

申请人： Bryan E. Laulicht ,  Sasha Bakhru

发明人： Bryan E. Laulicht ,  Sasha Bakhru

IPC分类号： B29B9/12 ,  B05B1/14

CPC分类号： B01J13/14 ,  B01J13/08

摘要： The present invention relates to the fields of controlled release of drugs, proteins, nucleic acids, and other pharmaceuticals. It also relates to delivery systems for these agents and other compounds. The invention also relates to stable encapsulation of cells and molecules. The invention provides a population of microstructures comprising a permeable polymer shell, wherein the standard variance in the volume of the microstructures is usually less than or equal to 20%, preferably 10%, of the mean, and wherein the diffusion characteristics of the polymer shell vary within the population of microstructures. It also provides for an apparatus and a method of forming a population of microstructures, which method for making microstructures by introducing drops of a polymer solution into a receiving solution under conditions that permit cross-linking of the polymer in the receiving solution. Microstructures of calcium-cross-linked alginate with a chitosin capsule are disclosed.

摘要翻译： 本发明涉及药物，蛋白质，核酸和其他药物的控制释放领域。 它还涉及这些试剂和其它化合物的递送系统。 本发明还涉及细胞和分子的稳定包封。 本发明提供了包含可渗透聚合物壳的微观组织群，其中微结构体积的标准差异通常小于或等于平均值​​的20％，优选10％，并且其中聚合物壳的扩散特性 在微观结构的群体内变化。 它还提供了一种形成微观结构群体的装置和方法，该方法通过在允许聚合物在接收溶液中交联的条件下将聚合物溶液的液滴引入接收溶液来制备微结构。 公开了钙交联藻酸盐与壳聚糖胶囊的微结构。