公开(公告)号：US07049448B2

公开(公告)日：2006-05-23

申请号：US10662980

申请日：2003-09-15

申请人： Buchi Reddy Reguri ,  Rajasekhar Kadaboina ,  Srinivas Reddy Gade ,  Babu Ireni

发明人： Buchi Reddy Reguri ,  Rajasekhar Kadaboina ,  Srinivas Reddy Gade ,  Babu Ireni

IPC分类号： C07D319/16 ,  C07D317/72 ,  C07D209/88

CPC分类号： C07D319/08

摘要： There is provided a process for preparation of a monoketal compound of the structure that includes reacting 1,4-cyclohexanedione of the structure with a diol of the structure in a halogenated organic solvent in the presence of an acid catalyst, wherein X is a substituted or unsubstituted ethylene or propylene. Various embodiments and variants are provided.

摘要翻译： 提供了一种制备该结构的单酮化合物的方法，该方法包括在酸催化剂存在下使该结构的1,4-环己二酮与该结构的二醇在卤代有机溶剂中反应，其中X是取代或 未取代的乙烯或丙烯。 提供了各种实施例和变型。

公开(公告)号：US20120165527A1

公开(公告)日：2012-06-28

申请号：US13388173

申请日：2010-08-04

申请人： Buchi Reddy Reguri ,  Muthulingam Arunagiri ,  Saravanakumar Kasiyappan Gurusamy ,  Kondalarao Ponnapally

发明人： Buchi Reddy Reguri ,  Muthulingam Arunagiri ,  Saravanakumar Kasiyappan Gurusamy ,  Kondalarao Ponnapally

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention relates to an improved process for the preparation of pure Paliperidone of formula (I). The present invention more specifically provides an improved process for the preparation of pure Paliperidone which may contain impurities in the acceptable level of pharmacopoeia requirement specifically 3-{2-[4-(5-Fluoro-benzo[d]isoxazol-3-yl]-piperidin-1-yl]-ethyl}-2-methyl-7,8-dihydro-6H-pyrido[1,2-a]pyrimidine-4,9-dione of Formula (IV).

摘要翻译： 本发明涉及制备式（I）的纯的哌啶酮的改进方法。 本发明更具体地提供了制备纯的哌啶酮的改进方法，其可以含有可接受的药典水平的杂质，特别是3- {2- [4-（5-氟 - 苯并[d]异恶唑-3-基] - 哌啶-1-基] - 乙基} -2-甲基-7,8-二氢-6H-吡啶并[1,2-a]嘧啶-4,9-二酮。

公开(公告)号：US20100063291A1

公开(公告)日：2010-03-11

申请号：US12619736

申请日：2009-11-17

申请人： Buchi Reddy Reguri ,  Satyanarayana Bollikonda ,  Veera Venkata Naga Chandra Sekhar Bulusu ,  Ravi Kumar Kasturi ,  Sanjeev Kumar Aavula

发明人： Buchi Reddy Reguri ,  Satyanarayana Bollikonda ,  Veera Venkata Naga Chandra Sekhar Bulusu ,  Ravi Kumar Kasturi ,  Sanjeev Kumar Aavula

IPC分类号： C07D215/14

CPC分类号： C07D215/18

摘要： A process for preparation of montelukast or a salt thereof is provided, the process including reacting a late intermediate compound which is 2-[1-[1-R-3-[2-(7 chloro quinolin-2-yl)vinyl [phenyl]-3-[2-methoxy carbonyl phenyl]propyl sulfonyl methyl]cyclo propyl]acetic acid or a salt thereof with methyl magnesium chloride or methyl magnesium bromide in an organic solvent. In one embodiment, the process includes reacting an earlier intermediate compound which is methyl 2-(3-R-(3-(2-(7-chloro 2-quinolinyl)-ethenyl)-3 hydroxy propyl)benzoate with methane sulfonyl chloride or toluene sulfonyl chloride to obtain a mesylated or tosylated derivative of the earlier intermediate compound; followed by a reaction of the mesylated or tosylated derivative with 1-mercapto methyl cyclopropane acetic acid in a polar solvent in a presence of a base to obtain the late intermediate compound.

摘要翻译： 提供了一种制备孟鲁司特或其盐的方法，该方法包括使2- [1- [1- [3- [2-（7-氯喹啉-2-基）乙烯基] [苯基 ] -3- [2-甲氧基羰基苯基]丙基磺酰基甲基]环丙基]乙酸或其盐与甲基氯化镁或甲基溴化镁在有机溶剂中反应。 在一个实施方案中，该方法包括使2-（3-R-（3-（2-（7-氯-2-喹啉基） - 乙烯基）-3-羟基丙基）苯甲酸甲酯与甲磺酰氯反应的较早中间体化合物或 甲磺酰氯，得到较早期中间体化合物的甲磺酰化或甲磺酰化衍生物;随后在极性溶剂中，在碱的存在下，使甲磺酰化或甲硅烷基化衍生物与1-巯基甲基环丙烷乙酸反应，得到后期中间体化合物 。

公开(公告)号：US20130012714A1

公开(公告)日：2013-01-10

申请号：US13578078

申请日：2011-02-04

申请人： Buchi Reddy Reguri ,  Sampath kumar Upparapalli ,  Thirumurugan Kunchithapatham ,  Sabarinathan Natarajan ,  Thiyagarajan Sambashivam ,  Suresh Munuswamy ,  Susi Swaminathan

发明人： Buchi Reddy Reguri ,  Sampath kumar Upparapalli ,  Thirumurugan Kunchithapatham ,  Sabarinathan Natarajan ,  Thiyagarajan Sambashivam ,  Suresh Munuswamy ,  Susi Swaminathan

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  C07D235/28

摘要： The present invention provides novel solvate of dexlansoprazole (or R-lansoprazole), particularly diol solvate and its hydrate form of dexlansoprazole (or R-lansoprazole) which is chemically known as (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole compound of the formula (I), as well as processes for the preparation thereof. The said solvates are useful in the preparation of dexlansoprazole with enhanced chiral purity and better HPLC purity with less sulphone impurity content.

摘要翻译： 本发明提供了右旋兰索唑（或R-兰索拉唑）特别是二醇溶剂合物及其水合物形式的右兰索拉唑（或R-兰索拉唑）的新型溶剂化物，其化学上称为（R）-2 - [[[3-甲基-4- （2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] -1H-苯并咪唑化合物及其制备方法。 所述溶剂合物可用于制备具有增强的手性纯度的右兰索拉唑和更好的HPLC纯度，较少的砜含量。