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公开(公告)号:US09107895B2
公开(公告)日:2015-08-18
申请号:US12843664
申请日:2010-07-26
申请人: Bulent Aydogan , Tijana Rajh
发明人: Bulent Aydogan , Tijana Rajh
IPC分类号: C07H23/00 , A61K33/24 , A61K31/7135 , A61K49/00 , A61K9/14 , A61K49/04 , A61P43/00 , A61K31/7004 , B82Y5/00
CPC分类号: A61K33/24 , A61K31/7004 , A61K49/0485 , B82Y5/00 , C07H23/00
摘要: Disclosed are compositions comprising nanoparticles and uses thereof. Such nanoparticles include gold nanoparticles conjugated to glucose or a glucose derivative, which are useful as contrast agents in imaging methods such as computed tomography (CT). Nanoparticles disclosed herein are useful in imaging various cells, tissues, and organs, and are particularly useful in imaging tumors and tumor cells in vitro and in vivo.
摘要翻译: 公开了包含纳米颗粒的组合物及其用途。 这样的纳米颗粒包括与葡萄糖或葡萄糖衍生物缀合的金纳米颗粒,其可用作成像方法如计算机断层摄影(CT)中的造影剂。 本文公开的纳米颗粒可用于成像各种细胞,组织和器官,并且特别可用于体外和体内成像肿瘤和肿瘤细胞。