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公开(公告)号：US20140142352A1
公开(公告)日：2014-05-22
申请号：US14084881
申请日：2013-11-20
摘要： Provided herein are processes for adjusting a fermentation medium to reduce the activity of one or more carboxylic acids. The processes comprise (a) providing a recombinant microorganism comprising an engineered butanol biosynthetic pathway, (b) contacting the recombinant microorganism with a fermentation medium whereby butanol is produced and wherein the fermentation medium comprises one or more carboxylic acids, and (c) adjusting the fermentation medium to reduce the activity of the one or more carboxylic acids. Also provided are processes for reducing the activity of one or more carboxylic acids in a feed. The processes comprise (a) providing a feed from a fermentation vessel, wherein the feed comprises a composition produced by a recombinant microorganism comprising an engineered butanol biosynthetic pathway, wherein the composition comprises butanol, water, and one or more carboxylic acids; and (b) adjusting the feed, wherein adjusting the feed reduces the activity of the one or more carboxylic acids.
摘要翻译： 本文提供了调节发酵培养基以降低一种或多种羧酸的活性的方法。 所述方法包括（a）提供包含工程改造的丁醇生物合成途径的重组微生物，（b）使重组微生物与发酵培养基接触，由此产生丁醇，其中发酵培养基包含一种或多种羧酸，和（c） 发酵培养基以降低一种或多种羧酸的活性。 还提供了降低进料中一种或多种羧酸的活性的方法。 所述方法包括（a）提供来自发酵容器的进料，其中所述进料包含由包含工程丁醇生物合成途径的重组微生物产生的组合物，其中所述组合物包含丁醇，水和一种或多种羧酸; 和（b）调节进料，其中调节进料降低了一种或多种羧酸的活性。
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公开(公告)号：US20170253846A1
公开(公告)日：2017-09-07
申请号：US15129059
申请日：2015-04-10
发明人： Adam Bernfeld , Keith H. Burlew , Anthony R. Calabria , Duncan Coffey , Benjamin Fuchs , Ana Paula Goes , Adam David Henry , Walter Tamulis , Joseph J. Zaher
CPC分类号： C12M39/00 , A61L2/04 , A61L2202/17 , B01D3/002 , B08B9/08 , C11D11/0041 , C12F3/00 , C12M21/12
摘要： The present disclosure is directed to methods, approaches, devices, equipment, and systems for minimizing or reducing contamination in facilities implementing fermentation or distillation processes. In embodiments, the facility is a biofuel plant that produces fermentation product such as product alcohol like butanol. In some embodiments, the methods, approaches, devices, equipment, and systems are operable to implement clean in place contamination (CIP) mitigation techniques that can also include sterilize in place (SIP) mitigation techniques to decontaminate equipment including surfaces of the equipment that come in contact with materials used in the production of product alcohols. Other cleaning and contamination minimizing techniques are also described.
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