公开(公告)号：US20120040858A1

公开(公告)日：2012-02-16

申请号：US13204358

申请日：2011-08-05

申请人： Byron D. FORD ,  Gregory Ford

发明人： Byron D. FORD ,  Gregory Ford

IPC分类号： C40B30/04 ,  C12Q1/48 ,  C12Q1/34 ,  G01N33/566

CPC分类号： G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/2871 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/60

摘要： Biomarkers for stroke and methods for their detection are disclosed. In one aspect, the present application discloses biomarkers for the diagnosis of stroke in a subject. In another aspect, the application discloses a method for the diagnosis of stroke in a subject. The method comprises detection of stroke biomarkers in cerebrospinal fluid, blood, serum or PMBCs of a subject. Also disclosed is a kit for the detection of biomarkers for the diagnosis of stroke in a subject.

摘要翻译： 公开了用于中风的生物标志物及其检测方法。 一方面，本申请公开了用于诊断受试者中风的生物标志物。 在另一方面，本申请公开了一种用于诊断受试者中风的方法。 该方法包括检测受试者的脑脊髓液，血液，血清或PMBCs中的中风生物标志物。 还公开了用于检测受试者中风的诊断的生物标志物的试剂盒。

公开(公告)号：US20100120692A1

公开(公告)日：2010-05-13

申请号：US12688351

申请日：2010-01-15

申请人： Byron D. FORD

发明人： Byron D. FORD

IPC分类号： A61K38/17 ,  A61P9/00

CPC分类号： A61K38/17 ,  Y10S977/915

摘要： Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.

摘要翻译： 已发现神经调节蛋白是一种已知的神经蛋白，用于改善或预防由机械或化学物质侵袭血管引起的损伤，并且当施用于脑脊髓液时，可以改善由中风或炎症引起的神经元组织的损伤。 另外，已经发现神经调节蛋白可用于增强从脑室到脑损伤部位的干细胞迁移。

公开(公告)号：US20090156500A1

公开(公告)日：2009-06-18

申请号：US12359773

申请日：2009-01-26

申请人： Byron D. FORD

发明人： Byron D. FORD

IPC分类号： A61K38/18 ,  A61P25/00

CPC分类号： A61K38/17 ,  Y10S977/915

摘要： Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.

摘要翻译： 已发现神经调节蛋白是一种已知的神经蛋白，用于改善或预防由机械或化学物质侵袭血管引起的损伤，并且当施用于脑脊髓液时，可以改善由中风或炎症引起的神经元组织的损伤。 另外，已经发现神经调节蛋白可用于增强从脑室到脑损伤部位的干细胞迁移。

公开(公告)号：US20110015186A1

公开(公告)日：2011-01-20

申请号：US12829056

申请日：2010-07-01

申请人： Byron D. FORD ,  Peter A. Ferchmin ,  Vesna A. Eterovic

发明人： Byron D. FORD ,  Peter A. Ferchmin ,  Vesna A. Eterovic

IPC分类号： A61K31/047 ,  A61K31/46 ,  A61K31/4425 ,  A61K31/5517 ,  A61P25/00

CPC分类号： A61K31/047 ,  A61K31/215 ,  A61K31/335 ,  A61K31/38 ,  A61K2300/00

摘要： A method and composition for protecting and/or treating neuroinjury are disclosed. In one aspect, the present application discloses a method for protecting and/or treating a subject from organophosphate-induced neuronal injury. The method comprises administering to a subject an effective amount of 4R cembranoid, 4S cembranoid or a cembranoid analogue. In another aspect, the application discloses neuroprotective pharmaceutical compositions for protecting and/or treating a subject from organophosphate-induced neuronal injury. A kit for protecting and treating a subject from organophosphate-induced neurodamage is also disclosed.

摘要翻译： 公开了用于保护和/或治疗神经损伤的方法和组合物。 一方面，本申请公开了一种用于保护和/或治疗受试者免受有机磷酸盐诱导的神经元损伤的方法。 该方法包括向受试者施用有效量的类似物的类似物，类似物或类似物。 在另一方面，本申请公开了用于保护和/或治疗受试者免受有机磷酸盐诱导的神经元损伤的神经保护性药物组合物。 还公开了用于保护和治疗受试者有机磷酸盐诱导的神经损伤的试剂盒。

公开(公告)号：US20100120691A1

公开(公告)日：2010-05-13

申请号：US12688287

申请日：2010-01-15

申请人： Byron D. FORD

发明人： Byron D. FORD

IPC分类号： A61K38/17 ,  A61P25/00

CPC分类号： A61K38/17 ,  Y10S977/915

摘要： Neuregulin, a known neuroprotein, has been found to ameliorate or prevent damage caused by mechanical or chemical assault to blood vessels and, when administered into the cerebral spinal fluid, can ameliorate damage to neuronal tissue caused by stroke or inflammation. Additionally, neuregulin has been found to be useful for enhancement of stem cell migration from the ventricle to the site of injury to the brain.