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    Chemically modified small molecules
    1.
    发明申请
    Chemically modified small molecules 审中-公开
    化学修饰的小分子

    公开(公告)号：US20060182692A1

    公开(公告)日：2006-08-17

    申请号：US11344404

    申请日：2006-01-30

    申请人： C. Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    发明人： C. Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    IPC分类号： A61K9/14 ,  A61L9/04

    CPC分类号： A61K9/007 ,  A61K31/167 ,  A61K31/485 ,  A61K47/60 ,  C07C41/24

    摘要： Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.

    摘要翻译： 通过肺途径改变施用于受试者的药物的全身吸收速率的方法，所述方法包括将亲水性聚合物与药物共价共轭，其中所述药物具有从肺中消除的半衰期小于约180 分钟，以形成药物 - 聚合物缀合物，其中药物 - 聚合物缀合物具有净亲水特性和约50至约20,000道尔顿的重均分子量，并且其中从药物的肺中消除的半衰期 - 聚合物缀合物比从药物肺消除的半衰期大至少约1.5倍，其中通过支气管肺泡灌洗测量肺部消除的半衰期，然后测定残留的肺部材料。

    Chemically Modified Small Molecules
    2.
    发明申请
    Chemically Modified Small Molecules 有权
    化学改性的小分子

    公开(公告)号：US20100210676A1

    公开(公告)日：2010-08-19

    申请号：US12710167

    申请日：2010-02-22

    申请人： C. Simone Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    发明人： C. Simone Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    IPC分类号： A61K31/485 ,  A61P25/36

    CPC分类号： A61K9/007 ,  A61K31/167 ,  A61K31/485 ,  A61K47/60 ,  C07C41/24

    摘要： Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.

    摘要翻译： 通过肺途径改变施用于受试者的药物的全身吸收速率的方法，所述方法包括将亲水性聚合物与药物共价共轭，其中所述药物具有从肺中消除的半衰期小于约180 分钟，以形成药物 - 聚合物缀合物，其中药物 - 聚合物缀合物具有净亲水特性和约50至约20,000道尔顿的重均分子量，并且其中从药物的肺中消除的半衰期 - 聚合物缀合物比从药物肺消除的半衰期大至少约1.5倍，其中通过支气管肺泡灌洗测量肺部消除的半衰期，然后测定残留的肺部材料。

    CHEMICALLY MODIFIED SMALL MOLECULES
    3.
    发明申请
    CHEMICALLY MODIFIED SMALL MOLECULES 审中-公开
    化学改性的小分子

    公开(公告)号：US20120088745A1

    公开(公告)日：2012-04-12

    申请号：US13271158

    申请日：2011-10-11

    申请人： C. Simone Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    发明人： C. Simone Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    IPC分类号： A61K31/16 ,  C07D489/08 ,  C07C43/13 ,  C07J5/00 ,  A61K31/573 ,  C07C233/21 ,  A61K31/485

    CPC分类号： A61K9/007 ,  A61K31/167 ,  A61K31/485 ,  A61K47/60 ,  C07C41/24

    摘要： Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.

    摘要翻译： 通过肺途径改变施用于受试者的药物的全身吸收速率的方法，所述方法包括将亲水性聚合物与药物共价共轭，其中所述药物具有从肺中消除的半衰期小于约180 分钟，以形成药物 - 聚合物缀合物，其中药物 - 聚合物缀合物具有净亲水特性和约50至约20,000道尔顿的重均分子量，并且其中从药物的肺中消除的半衰期 - 聚合物缀合物比从药物肺消除的半衰期大至少约1.5倍，其中通过支气管肺泡灌洗测量肺部消除的半衰期，然后测定残留的肺部材料。

    Chemically modified small molecules
    4.
    发明授权
    Chemically modified small molecules 有权
    化学修饰的小分子

    公开(公告)号：US08067431B2

    公开(公告)日：2011-11-29

    申请号：US12710167

    申请日：2010-02-22

    申请人： C. Simone Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    发明人： C. Simone Fishburn ,  David Lechuga-Ballesteros ,  Tacey Viegas ,  Mei-Chang Kuo ,  Yuan Song ,  Hema Gursahani ,  Chester Leach

    IPC分类号： A61K31/485 ,  C07D489/08

    CPC分类号： A61K9/007 ,  A61K31/167 ,  A61K31/485 ,  A61K47/60 ,  C07C41/24

    摘要： Methods of modifying the rate of systemic absorption of a drug administered to a subject by a pulmonary route, the method comprising covalently conjugating a hydrophilic polymer to a drug, wherein the drug has a half-life of elimination from the lung of less than about 180 minutes, to form a drug-polymer conjugate, wherein the drug-polymer conjugate has a net hydrophilic character and a weight average molecular weight of from about 50 to about 20,000 Daltons, and wherein the half-life of elimination from the lung of the drug-polymer conjugate is at least about 1.5-fold greater than the half-life of elimination from the lung of the drug, wherein the half-life of elimination from the lung is measured by bronchoalveolar lavage followed by assaying residual lung material.

    摘要翻译： 通过肺途径改变施用于受试者的药物的全身吸收速率的方法，所述方法包括将亲水性聚合物与药物共价共轭，其中所述药物具有从肺中消除的半衰期小于约180 分钟，以形成药物 - 聚合物缀合物，其中药物 - 聚合物缀合物具有净亲水特性和约50至约20,000道尔顿的重均分子量，并且其中从药物的肺中消除的半衰期 - 聚合物缀合物比从药物肺消除的半衰期大至少约1.5倍，其中通过支气管肺泡灌洗测量肺部消除的半衰期，然后测定残留的肺部材料。