公开(公告)号：US20200179420A1

公开(公告)日：2020-06-11

申请号：US16345666

申请日：2017-10-27

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Mitchell GUTTMAN ,  Chun-Kan CHEN

IPC: A61K31/706 ,  C12N15/01 ,  A61K31/405 ,  A61K31/165 ,  A61K31/473

Abstract: A reactivation composition for activating or re-activating expression of a silenced X chromosome gene in a cell includes a non-cytotoxic histone deacetylase (HDAC) inhibitor. The reactivation composition includes the non-cytotoxic HDAC inhibitor and may further include a DNA methylation inhibitor. A method of activating or re-activating expression of a silenced X chromosome gene in a cell includes administering a reactivation composition including a non-cytotoxic HDAC inhibitor. The method of activating or re-activating expression of a silenced X chromosome gene may further includes administering a reactivation composition that includes a non-cytotoxic HDAC inhibitor and an inhibitor of DNA methylation.