公开(公告)号：US11028107B2

公开(公告)日：2021-06-08

申请号：US15438929

申请日：2017-02-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Wenbo Liu ,  David P. Schuman ,  Brian M. Stoltz ,  Robert H. Grubbs

IPC: C07F7/08 ,  C07F7/18

Abstract: The present invention is directed to compositions for silylating organic substrates containing C—H or O—H bonds, especially heteroaromatic substrates. The compositions are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide and metal alkoxide bases. In some embodiments, the preconditioning results in the formation of reactive silicon hydride species.

公开(公告)号：US20210323983A1

公开(公告)日：2021-10-21

申请号：US17332394

申请日：2021-05-27

Applicant: California Institute Of Technology

Inventor： Anton Toutov ,  Wenbo Liu ,  David P. Schuman ,  Brian M. Stoltz ,  Robert H. Grubbs

IPC: C07F7/08 ,  C07F7/18

Abstract: The present disclosure is directed to methods of silylating organic substrates containing C—H or O—H bonds. In some embodiments, the methods use compositions that are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide, metal alkoxide, metal silanoates, potassium amides, and/or graphitic potassium bases.

公开(公告)号：US09764995B2

公开(公告)日：2017-09-19

申请号：US15375747

申请日：2016-12-12

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Wenbo Liu ,  Brian M. Stoltz ,  Robert H. Grubbs ,  Kerry Betz ,  David P. Schuman

IPC: C07B47/00 ,  C07F7/08

CPC classification number: C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates using at least alkoxide base, preferably a potassium alkoxide base and at least one organodisilane and (b) at least one alkoxide base. Both methods and compositions for affecting these transformations are disclosed.

公开(公告)号：US09556080B2

公开(公告)日：2017-01-31

申请号：US14972653

申请日：2015-12-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Anton Toutov ,  Wenbo Liu ,  Brian M. Stoltz ,  Robert H. Grubbs ,  Kerry Betz ,  David P. Schuman

IPC: C07B47/00 ,  C07F7/08 ,  C07D209/12

CPC classification number: C07B47/00 ,  C07D209/12 ,  C07F5/04 ,  C07F7/0827

Abstract: The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates, said system consisting essentially of a mixture of (a) at least one organodisilane and (b) at least alkoxide base, preferably a potassium alkoxide base, and said methods comprising contacting a quantity of the organic substrate with a mixture consisting essentially of (a) at least one organodisilane and (b) at least one alkoxide base, preferably a potassium alkoxide, under conditions sufficient to silylate the heteroaromatic substrate.

Abstract translation: 本发明描述了用于甲硅烷基化杂芳族有机底物的化学系统和方法，所述系统基本上由（a）至少一种有机硅烷和（b）至少烷氧基，优选烷醇钾碱的混合物组成，所述方法包括使 基本上由（a）至少一种有机硅烷和（b）至少一种醇盐碱，优选烷氧基钾，在足以使所述杂芳族底物甲硅烷基化的条件下混合的混合物的有机底物的量。