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公开(公告)号：US11028107B2
公开(公告)日：2021-06-08
申请号：US15438929
申请日：2017-02-22
发明人： Anton Toutov , Wenbo Liu , David P. Schuman , Brian M. Stoltz , Robert H. Grubbs
摘要： The present invention is directed to compositions for silylating organic substrates containing C—H or O—H bonds, especially heteroaromatic substrates. The compositions are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide and metal alkoxide bases. In some embodiments, the preconditioning results in the formation of reactive silicon hydride species.
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公开(公告)号：US10072030B2
公开(公告)日：2018-09-11
申请号：US15375716
申请日：2016-12-12
发明人： Anton Toutov , Kerry Betz , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
CPC分类号： C07F7/0827 , C07F17/02 , C07J1/0096 , C07J7/0005 , C07J51/00 , C07J75/00
摘要： The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl C—H bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali metal hydride under conditions sufficient to form a silylated terminal alkynyl moiety. The methods are operable in the presence or substantially absence of transition-metal compounds. The systems associated with these methods are also disclosed.
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公开(公告)号：US11312733B2
公开(公告)日：2022-04-26
申请号：US17074717
申请日：2020-10-20
发明人： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC分类号： C07F7/08 , C07D209/12
摘要： The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
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公开(公告)号：US20210323983A1
公开(公告)日：2021-10-21
申请号：US17332394
申请日：2021-05-27
发明人： Anton Toutov , Wenbo Liu , David P. Schuman , Brian M. Stoltz , Robert H. Grubbs
摘要： The present disclosure is directed to methods of silylating organic substrates containing C—H or O—H bonds. In some embodiments, the methods use compositions that are derived from the preconditioning of mixtures of hydrosilanes or organodisilanes with bases, including metal hydroxide, metal alkoxide, metal silanoates, potassium amides, and/or graphitic potassium bases.
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公开(公告)号：US10059726B2
公开(公告)日：2018-08-28
申请号：US15166405
申请日：2016-05-27
发明人： Anton Toutov , Wenbo Liu , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Robert H. Grubbs
IPC分类号： C07F7/08
CPC分类号： C07F7/0829
摘要： The present invention is directed to a mild, efficient, and general direct C(sp2)-H bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal olefinic C—H bond, with a mixture of at least one organosilane, organosilane, or mixture thereof and an alkali metal alkoxide or alkali metal hydroxide, such that the contacting results in the formation of a silylated olefinic product. The systems associated with these methods are also disclosed.
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公开(公告)号：US20220185828A1
公开(公告)日：2022-06-16
申请号：US17688122
申请日：2022-03-07
发明人： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC分类号： C07F7/08 , C07D209/12
摘要： The present disclosure describes methods for silylating aromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
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公开(公告)号：US10919917B2
公开(公告)日：2021-02-16
申请号：US16705408
申请日：2019-12-06
发明人： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC分类号： C07F7/08 , C07D209/12
摘要： The present disclosure describes methods for silylating heteroaromatic derivatives, comprising the use of hydrosilanes and potassium hydroxide.
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公开(公告)号：US10513531B2
公开(公告)日：2019-12-24
申请号：US16159298
申请日：2018-10-12
发明人： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC分类号： C07F7/08 , C07D209/12
摘要： The present disclosure describes novel silylated heteroaromatic derivatives, including those prepared by methods comprising the use of hydrosilanes and at least one strong base, the definition of strong base now also including hydroxide, especially KOH.
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公开(公告)号：US10125153B2
公开(公告)日：2018-11-13
申请号：US15804275
申请日：2017-11-06
发明人： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC分类号： C08G75/00 , C07F7/08 , C07D209/12
摘要： The present invention describes chemical systems and methods for silylating N—H bonds of aliphatic amines, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one hydroxide, especially KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to replace an N—H bond with a silyl N—Si bond.
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公开(公告)号：US09809607B2
公开(公告)日：2017-11-07
申请号：US14818417
申请日：2015-08-05
发明人： Anton Toutov , Kerry Betz , Alexey Fedorov , Brian M. Stoltz , Wenbo Liu , Robert H. Grubbs
IPC分类号： C08G75/00 , C07F7/08 , C07D209/12
CPC分类号： C07F7/0801 , C07D209/12 , C07F7/0827 , C07F7/0832
摘要： The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one organosilane and (b) at least one strong base, the definition of strong base now also including KOH, said system being preferably, but not necessarily substantially free of a transition-metal compound, and said methods comprising contacting a quantity of the organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate.
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