公开(公告)号：US20180371416A1

公开(公告)日：2018-12-27

申请号：US16044182

申请日：2018-07-24

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Loran Solorio ,  Phuong Dang

IPC: C12N5/077

Abstract: A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregate. The nanoparticles and/or microparticles act as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate allowing the cell aggregate to be readily manipulated and formed into tissue constructs with defined architectures.

公开(公告)号：US10030228B2

公开(公告)日：2018-07-24

申请号：US13863364

申请日：2013-04-15

Applicant: Case Western Reserve University

Inventor： Eben Alsberg ,  Loran Solorio ,  Phuong Dang

IPC: C12N5/077

Abstract: A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and degradable nanoparticles and/or microparticles that are incorporated within the cell aggregate. The nanoparticles and/or microparticles act as a bulking agent and/or provide bioactive agents or signals within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate and/or regulate cell function within the aggregate allowing the cell aggregate to be readily manipulated and formed into tissue constructs with defined architectures and potential tissue specific functionality.