公开(公告)号：US12151047B2

公开(公告)日：2024-11-26

申请号：US16641056

申请日：2018-07-25

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Jung-Youn Shin ,  Robyn Marks ,  Mitchell Hopkins ,  Hongyun Park

IPC: A61L27/44 ,  A61L27/20 ,  A61L27/26 ,  A61L27/36 ,  A61L27/38 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  C08B37/00 ,  C08G65/00 ,  C08H1/06 ,  C08L5/04 ,  C08L89/06

Abstract: A composition includes a hydrogel that includes a plurality biodegradable natural polymer macromers crosslinked with a first agent and optionally a plurality of cells dispersed in the crosslinked macromers, the microgels are capable of being crosslinked with a second agent that is different than the first crosslinking agent.

公开(公告)号：US11471565B2

公开(公告)日：2022-10-18

申请号：US15258666

申请日：2015-03-09

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  WORCESTER POLYTECHNIC INSTITUTE

Inventor： Eben Alsberg ,  Anna D. Dikina ,  Marsha W. Rolle

IPC: A61L27/38 ,  A61L27/54 ,  C12N5/00

Abstract: A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.

公开(公告)号：US20220298471A1

公开(公告)日：2022-09-22

申请号：US17698539

申请日：2022-03-18

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon

IPC: C12N5/00 ,  B01J2/10

Abstract: A method of forming a gel particle slurry includes providing a first solution that includes a cross-linkable hydrogel polymer macromer and an optional first crosslinker in a first depot and optionally a second solution in a second depot that is separated from the first depot by a mixing unit that includes a mixing element; and reversibly transferring the first solution and the optional second solution through the mixing unit between the first depot and the second depot such that the first solution and the optional second solution are mixed and agitated to form the gel particle slurry.

公开(公告)号：US20220054462A1

公开(公告)日：2022-02-24

申请号：US17312196

申请日：2019-12-10

Applicant: Eben ALSBERG ,  Oju JEON ,  The Regents of the University of California ,  Case Western Reserve University

Inventor： Sarah Knox ,  Chelsea S. Bahney ,  Eben Alsberg ,  Oju Jeon

IPC: A61K31/439 ,  A61K31/4178 ,  A61K9/06 ,  A61K47/36 ,  A61K9/00 ,  A61K31/27

Abstract: A method is provided for promoting salivary gland regeneration in a subject in need thereof comprising administering to acinar progenitor cells of the salivary gland at least one of a cholinergic agonist or muscarinic agonist to promote acinar cell generation. In particular, formulations comprising a muscarinic agonist such as cevimeline encapsulated in an alginate hydrogel can be formulated for local administration to a salivary gland and used in treatment of xerostomia.

公开(公告)号：US10512708B2

公开(公告)日：2019-12-24

申请号：US14773659

申请日：2014-03-07

Applicant: Case Western Reserve University

Inventor： Eben Alsberg ,  Oju Jeon

IPC: A61L24/04 ,  A61L24/00

Abstract: A bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized, acrylated or methacrylated, natural polymer. Bioadhesives are natural or synthetic materials that can be used for soft tissue repair to create a seal preventing leakage of biological fluids or to reinforce anatomic integrity as an attractive alternative to sutures and staples. The most widely used bioadhesives are fibrin, cyanoacrylates, and albumin-glutaraldehyde bioadhesives.

公开(公告)号：US20190112434A1

公开(公告)日：2019-04-18

申请号：US16218051

申请日：2018-12-12

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon

IPC: C08J3/075 ,  C08J3/24 ,  A61L27/36 ,  A61L27/38 ,  C08L89/00 ,  C08L5/04 ,  C08K3/32

Abstract: An elastomeric nanocomposite hydrogel includes first natural polymer macromers covalently crosslinked with second natural polymer macromer and physically crosslinked with a plurality of inorganic nanoparticles. The elastomeric nanocomposite hydrogel is cytocompatible, and, upon degradation, produce substantially non-toxic products.

公开(公告)号：US20190054206A1

公开(公告)日：2019-02-21

申请号：US16107756

申请日：2018-08-21

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Oju Jeon ,  Keewon Lee

IPC: A61L27/20 ,  A61L27/54

Abstract: A method for forming a bioactive agent spatially patterned includes providing a photocrosslinkable hydrogel that includes a photocrosslinkable base polymer, photocrosslinkable bioactive agent coupling polymer macromers, and at least one bioactive agent that couples to the photocrosslinkable bioactive agent coupling polymer macromer, an selectively exposing discrete portions of the photocrosslinkable hydrogel to actinic radiation effective to initiate cross-linking of the base polymer and the bioactive agent coupling polymer macromers at the exposed portions.

公开(公告)号：US11944716B2

公开(公告)日：2024-04-02

申请号：US17544544

申请日：2021-12-07

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Eben Alsberg ,  Rui Tang

IPC: A61K9/50 ,  A61K47/02 ,  A61K47/42 ,  A61L27/24 ,  A61L27/36 ,  A61L27/54 ,  C07K14/78 ,  C12N5/00 ,  B82Y5/00 ,  B82Y40/00 ,  C08J3/075

CPC classification number: A61L27/24 ,  A61K9/50 ,  A61K9/5084 ,  A61K47/02 ,  A61K47/42 ,  A61L27/36 ,  A61L27/54 ,  C07K14/78 ,  C12N5/0068 ,  A61K9/501 ,  B82Y5/00 ,  B82Y40/00 ,  C08J3/075 ,  C08J2389/00 ,  C12N2533/54

Abstract: A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid nanoparticles, the particulate shell inhibiting aggregation of the microparticles in an aqueous medium and being permeable to allow release of agents from the hydrogel inner core.

公开(公告)号：US20220218874A1

公开(公告)日：2022-07-14

申请号：US17410523

申请日：2021-08-24

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Inventor： Eben Alsberg ,  Oju Jeon ,  Ralph Marcucio ,  Chelsea Bahney ,  Diane Hu ,  Sarah Knox

IPC: A61L27/38 ,  A61K31/221 ,  A61K31/5578 ,  A61K35/28 ,  A61K35/32 ,  A61K38/20

Abstract: A method of modulating transdifferentiation of chondrocytes to osteoblast includes administering to the chondrocytes an agent that modulates GP130 receptor signaling and expression of at least one of Sox2, Oct4, or Nanog of the chondrocytes.

公开(公告)号：US20220088264A1

公开(公告)日：2022-03-24

申请号：US17544492

申请日：2021-12-07

Applicant: Case Western Reserve University

Inventor： Eben Alsberg ,  Oju Jeon

IPC: A61L24/04 ,  A61L24/00

Abstract: A bioadhesive includes a crosslinked biodegradable hydrogel that includes a plurality of oxidized, acrylated or methacrylated, natural polymer.