专利检索 ap:("CAYMAN CHEMICAL COMPANY INCORPORATED") AND inv:"Victor Fedij" 第 1 页

1.

发明授权
Amine salts of a prostacyclin analog 有权

公开(公告)号：US10155716B2

公开(公告)日：2018-12-18

申请号：US15852922

申请日：2017-12-22

申请人： CAYMAN CHEMICAL COMPANY INCORPORATED

发明人： Gilles Chambournier , Gregory William Endres , Kirk William Hering , Victor Fedij , Hussein Mahmoud Mahmoud

IPC分类号： C07C29/09 , C07C59/72 , C07F7/18 , C07C41/26 , C07C51/09 , C07C51/347 , C07C51/41 , C07C45/29 , C07C51/00

摘要： The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.

2.

发明申请
METHODS OF SYNTHESIZING A PROSTACYCLIN ANALOG 审中-公开

公开(公告)号：US20180141889A1

公开(公告)日：2018-05-24

申请号：US15874093

申请日：2018-01-18

申请人： CAYMAN CHEMICAL COMPANY INCORPORATED

发明人： Kirk William Hering , Gilles Chambournier , Gregory William Endres , Victor Fedij , Thomas James Krell, II , Hussein Mahmoud Mahmoud

IPC分类号： C07C51/347 , C07D301/00 , C07C205/57 , C07C45/29 , C07C41/44 , C07D303/14 , C07D317/22 , C07C51/41 , C07C51/09 , C07C41/26 , C07D301/32 , C07F7/18 , C07D303/16 , C07C59/72 , C07C43/23

摘要： The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

3.

发明授权
Methods of synthesizing a prostacyclin analog 有权

公开(公告)号：US09908834B2

公开(公告)日：2018-03-06

申请号：US15583457

申请日：2017-05-01

申请人： CAYMAN CHEMICAL COMPANY INCORPORATED

发明人： Kirk William Hering , Gilles Chambournier , Gregory William Endres , Victor Fedij , Thomas James Krell, II , Hussein Mahmoud Mahmoud

IPC分类号： C07C41/26 , C07D303/16 , C07C51/347 , C07D301/00 , C07C45/29 , C07C41/44 , C07D301/32 , C07C205/57 , C07F7/18 , C07D317/22 , C07D303/14 , C07C51/09 , C07C51/41

CPC分类号： C07C51/347 , C07C41/26 , C07C41/44 , C07C45/29 , C07C51/09 , C07C51/412 , C07C205/57 , C07C2603/14 , C07D301/00 , C07D301/32 , C07D303/14 , C07D303/16 , C07D317/22 , C07F7/1804 , C07C59/72 , C07C43/23

摘要： The present invention provides processes for preparing a prostacyclin analog of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.

4.

发明授权
Methods of synthesizing a prostacyclin analog 有权

公开(公告)号：US10450257B2

公开(公告)日：2019-10-22

申请号：US15874093

申请日：2018-01-18

申请人： CAYMAN CHEMICAL COMPANY INCORPORATED

发明人： Kirk William Hering , Gilles Chambournier , Gregory William Endres , Victor Fedij , Thomas James Krell, II , Hussein Mahmoud Mahmoud

IPC分类号： C07C51/347 , C07D301/32 , C07C41/44 , C07C45/29 , C07D301/00 , C07F7/18 , C07C205/57 , C07C41/26 , C07C51/09 , C07C51/41 , C07D317/22 , C07D303/14 , C07D303/16

摘要： The present invention provides processes for preparing a prostacyclin analog of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.