公开(公告)号：US10550196B2

公开(公告)日：2020-02-04

申请号：US15306664

申请日：2015-04-27

Applicant: CCAM BIOTHERAPEUTICS LTD.

Inventor： Tehila Ben-Moshe ,  Yair Sapir ,  Ilana Mandel ,  Gal Markel ,  Jacob Schachter ,  Rona Ortenberg ,  Francis Joseph Carr ,  Robert George E. Holgate ,  Timothy David Jones

IPC: C07K16/42 ,  C07K16/30 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68 ,  A61K39/00 ,  G01N33/574 ,  C07K16/28

Abstract: Humanized antibodies, capable of specific binding to human CEACAM1 molecules containing human-to-murine back-mutations in non-CDR variable regions, and their encoding polynucleotide sequences are provided. Pharmaceutical compositions comprising these antibodies as well as methods of their use in treating and diagnosing cancer and other conditions are also provided.

公开(公告)号：US10081679B2

公开(公告)日：2018-09-25

申请号：US15039022

申请日：2014-11-25

Applicant: CCAM BIOTHERAPEUTICS LTD.

Inventor： Tehila Ben-Moshe ,  Yair Sapir ,  Ilana Mandel ,  Edna Meilin

IPC: A61K39/395 ,  C07K16/28 ,  A61K35/17 ,  A61K39/00 ,  A61K35/12

CPC classification number: C07K16/2803 ,  A61K35/17 ,  A61K39/39558 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2818 ,  C07K16/2827 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention provides compositions comprising anti-CEACAM1 antibodies, compositions comprising antibodies capable of inhibiting or blocking the interaction between PD-1 and its ligands, and methods for their combined use in treating cancer.