公开(公告)号：US20230279440A1

公开(公告)日：2023-09-07

申请号：US17996701

申请日：2021-05-06

申请人： CELLECTIS S.A.

发明人： Alexandre JUILLERAT ,  Philippe DUCHATEAU ,  Patrick HONG ,  Laurent POIROT ,  Brian BUSSER ,  Alex BOYNE

IPC分类号： C12N15/90 ,  C12N15/86

CPC分类号： C12N15/907 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2830/42

摘要： The present disclosure provides methods to genetically modify cells by insertion of an artificial exon (ArtEx) for delivery of therapeutic proteins in specific cell types and more particularly engineered cells for expression of a transgene into the brain of a patient.

公开(公告)号：US20230279350A1

公开(公告)日：2023-09-07

申请号：US18016972

申请日：2021-07-30

申请人： CELLECTIS S.A.

发明人： André CHOULIKA ,  Laurent POIROT ,  Beatriz ARANDA ORGILLES ,  Philippe DUCHATEAU

IPC分类号： C12N5/0783 ,  C07K16/28 ,  A61P35/00

CPC分类号： C12N5/0636 ,  C07K16/2887 ,  C07K16/2896 ,  A61P35/00 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2319/03

摘要： The present invention concerns new engineered immune cells expressing two CARs directed against two different targets, polynucleotides for preparing said immune cells, pharmaceutical compositions comprising said immune cells, and the use of said immune cells in the treatment of cancers.

公开(公告)号：US20240197880A1

公开(公告)日：2024-06-20

申请号：US18556957

申请日：2022-04-29

申请人： CELLECTIS S.A.

发明人： Beatriz ARANDA-ORGILLES ,  Tomasz KURCON ,  Laurent POIROT

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  C12N15/90

CPC分类号： A61K39/46447 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/4631 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/3092 ,  C12N5/0636 ,  C12N15/907 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/30 ,  C12N2501/2302

摘要： The present invention relates to genetically engineered immune cells expressing new anti-MUC1 chimeric antigen receptors and their use in the treatment of solid tumors, particularly suited for allogeneic cell immunotherapy.

公开(公告)号：US20230248825A1

公开(公告)日：2023-08-10

申请号：US18005284

申请日：2021-07-23

申请人： CELLECTIS S.A.

发明人： Shipra DAS ,  Sumin JO ,  Alexandre JUILLERAT ,  Julien VALTON ,  Laurent POIROT ,  Philippe DUCHATEAU

IPC分类号： A61K39/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90 ,  C12N5/0783 ,  C12N15/113 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/4633 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C12N5/0636 ,  A61K39/4611 ,  A61K39/4643 ,  C12N15/1138 ,  A61K39/3955 ,  A61K39/4631 ,  A61P35/00 ,  C12N2800/80 ,  C12N2310/20 ,  C12N2506/11 ,  C12N2501/515 ,  C12N2501/51 ,  C12N2501/2302 ,  A61K2039/5158 ,  C12N2310/531 ,  C12N2310/14

摘要： The invention relates to therapeutic compositions for allogeneic cellular therapy comprising TCR deficient T-cells, which are genetically engineered to express immune cell engagers, and methods related thereto.