公开(公告)号：US20210059142A1

公开(公告)日：2021-03-04

申请号：US17098210

申请日：2020-11-13

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US20150272076A1

公开(公告)日：2015-10-01

申请号：US14439420

申请日：2013-10-31

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H5/12 ,  A01H1/06 ,  C12P21/00

CPC classification number: A01H5/12 ,  A01H1/06 ,  C12N9/22 ,  C12N15/01 ,  C12N15/8218 ,  C12N15/8257 ,  C12N15/8258 ,  C12P21/00 ,  C12P21/005

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract translation: 提供材料和方法用于制造适合于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。

公开(公告)号：US11576317B2

公开(公告)日：2023-02-14

申请号：US17098210

申请日：2020-11-13

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  A01H6/82 ,  A01H5/12 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US11555198B2

公开(公告)日：2023-01-17

申请号：US14439420

申请日：2013-10-31

Applicant: CELLECTIS SA ,  MEDICAGO INC.

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-Andre D'Aoust

IPC: A01H1/06 ,  C12N15/82 ,  C12N15/01 ,  C12N9/22 ,  C12P21/00

Abstract: Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

公开(公告)号：US20140120578A1

公开(公告)日：2014-05-01

申请号：US14068731

申请日：2013-10-31

Applicant: Medicago Inc. ,  Cellectis SA

Inventor： Luc Mathis ,  Daniel F. Voytas ,  Jin Li ,  Feng Zhang ,  Thomas Stoddard ,  Marc-André D'Aoust

IPC: C12N15/82 ,  C12N15/01 ,  C12P21/00

Abstract: Materials and Methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.

Abstract translation: 提供材料和方法用于制备适于产生适于施用于人和动物的治疗性多肽的植物（例如烟草属），特别是通过在编码木糖基转移酶和岩藻糖基转移酶的基因中产生TAL效应子内切核酸酶诱导的突变。