公开(公告)号：US11382848B2

公开(公告)日：2022-07-12

申请号：US16480331

申请日：2018-01-30

申请人： CHEMCOM S.A. ,  GIVAUDAN S.A.

发明人： Pierre Chatelain ,  Markus Gautschi ,  Thierry Granier ,  Yannick Quesnel ,  Charles Stanley Sell ,  Alex Veithen

IPC分类号： A61K8/34 ,  A61K8/36 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/42 ,  A61Q15/00 ,  C07C33/20 ,  C07C49/217 ,  C07C57/03 ,  C07C69/003 ,  C07C233/09 ,  C07C255/50 ,  C11B9/00

摘要： The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.

公开(公告)号：US11867685B2

公开(公告)日：2024-01-09

申请号：US16770457

申请日：2018-12-05

申请人： CHEMCOM S.A.

发明人： Sandra Huysseune ,  Alex Veithen ,  Yannick Quesnel

IPC分类号： G01N33/50

CPC分类号： G01N33/5008

摘要： The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.