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公开(公告)号:US20210395175A1
公开(公告)日:2021-12-23
申请号:US17163810
申请日:2021-02-01
IPC分类号: C07C31/27 , C07C61/12 , C07C47/34 , C07C309/25 , C07F9/24 , C07D261/12 , C07C59/105 , C07C33/26 , C07C47/19 , C07C69/675 , C07C69/003 , C07C69/017 , C07C309/08 , C07F9/11 , C07C309/24 , C07F9/12 , C07D495/04 , C07C255/00 , C07D257/04 , C07D261/08 , C07D305/12 , C07D307/33 , C07C59/01 , C07D309/30 , A61K31/194 , A61K31/23 , A61K31/20 , A61K31/191 , C07C31/20 , C07C31/22 , C07C31/24 , C07C59/11 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C62/06 , C07C65/17 , C07C69/757 , C07D213/80 , C07D309/10 , C07D309/12 , C07D405/12 , C07F9/09 , C07F9/117 , C07F9/44 , C07C59/245 , C07C62/02
摘要: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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公开(公告)号:US20210078965A1
公开(公告)日:2021-03-18
申请号:US16620219
申请日:2018-06-08
申请人: Caroline VAN HAAFTEN
发明人: Caroline VAN HAAFTEN
IPC分类号: C07D307/83 , C07C49/553 , C07C69/003 , C07C57/26
摘要: The present invention is directed to methods for the preparation of eremophila-1(10)-11(13)-dien-12,8β-olide (EPD) and analogues thereof.
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公开(公告)号:US10590062B1
公开(公告)日:2020-03-17
申请号:US16188976
申请日:2018-11-13
IPC分类号: C07C67/39 , C07C67/44 , B01J31/22 , C07C69/003 , C07C69/013
摘要: A process for making methyl esters in high yields is provided. The process comprises contacting aliphatic or aromatic aldehydes and methanol with an iron catalyst, to catalyze the dehydrogenative coupling between aliphatic or aromatic aldehydes and methanol. The reaction is highly selective (
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公开(公告)号:US10435349B2
公开(公告)日:2019-10-08
申请号:US16043308
申请日:2018-07-24
发明人: Sumit Chakraborty , Steven J. Adams , Robert Thomas Hembre , Scott Donald Barnicki , Michael Richard Laningham , Gerarld Wayne Ollis , Randy Lynn Jennings
IPC分类号: C07C69/013 , C07C69/003 , C07C67/00 , C07F17/00 , C07F15/00 , B01J31/24 , C07F15/02 , B01J31/18 , B01J31/20
摘要: A process for preparing a variety of secondary and tertiary alkyl formate esters via the coupling of methanol and secondary (or tertiary) alcohols. Iron-based catalysts, supported by pincer ligands, are employed to produce these formate esters in high yields and unprecedentedly high selectivities (>99%). Remarkably, the coupling strategy is also applicable to bulkier tertiary alcohols, which afford corresponding tertiary formate esters in moderately high yields and high selectivities.
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公开(公告)号:US20190263742A1
公开(公告)日:2019-08-29
申请号:US16142547
申请日:2018-09-26
IPC分类号: C07C31/27 , A61K31/20 , C07C69/757 , A61K31/194 , A61K31/23 , C07C61/12 , C07C47/19 , C07C69/003 , C07C69/017 , C07C47/34 , C07D261/12 , C07C69/675 , C07D261/08 , C07C33/26 , C07F9/24 , C07C309/24 , C07C309/25 , C07F9/12 , C07C309/08 , C07C59/01 , C07C59/105 , C07C59/245 , C07D213/80 , C07C62/06 , C07F9/44 , C07F9/09 , C07F9/117 , C07C59/29 , C07D405/12 , C07C65/17 , A61K31/191 , C07C59/46 , C07C31/24 , C07C59/11 , C07C31/20 , C07C59/48 , C07D309/12 , C07D309/10 , C07C59/54 , C07C31/22 , C07C59/285 , C07C62/02
摘要: The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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6.
公开(公告)号:US20190084908A1
公开(公告)日:2019-03-21
申请号:US15950608
申请日:2018-04-11
IPC分类号: C07C31/27 , C07D261/12 , A61K31/23 , C07C309/25 , C07C47/34 , C07C61/12 , C07C59/01 , C07D261/08 , C07F9/24 , C07F9/12 , C07C309/24 , C07C309/08 , C07C69/017 , C07C69/003 , C07C69/675 , C07C47/19 , C07C33/26 , C07C59/105 , C07F9/44 , C07F9/117 , C07F9/09 , C07D405/12 , C07D309/12 , C07D309/10 , C07D213/80 , C07C69/757 , C07C65/17 , C07C62/06 , C07C62/02 , C07C59/54 , C07C59/48 , C07C59/46 , C07C59/29 , C07C59/285 , C07C59/245 , C07C59/11 , C07C31/24 , C07C31/22 , C07C31/20 , A61K31/20 , A61K31/194 , A61K31/191
摘要: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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公开(公告)号:US09981937B2
公开(公告)日:2018-05-29
申请号:US15539338
申请日:2015-12-08
申请人: Henkel AG & Co. KGaA
IPC分类号: A61K8/18 , A61K8/00 , C07D317/34 , C11B9/00 , C07C69/003 , C07C69/74
CPC分类号: C07D317/34 , C07C69/003 , C07C69/74 , C11B9/0076
摘要: The disclosure relates to special orthoformic acid esters of formula (I), as defined herein, which can be used as thermally labile and acid-labile fragrance storage substances. The disclosure further relates to detergents and cleaning agents, cosmetic agents and air freshening products containing such orthoformic acid esters, as well as to a method for lastingly fragrancing surfaces.
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公开(公告)号:US09950986B2
公开(公告)日:2018-04-24
申请号:US15126182
申请日:2015-03-16
IPC分类号: C07C69/675 , C07C69/21 , C07C69/33 , C12P19/44 , C12P7/62 , C12R1/645 , A01N37/36 , C07C69/003 , A61K31/191
CPC分类号: C07C69/675 , A01N37/36 , A61K31/191 , C07C69/003 , C07C69/21 , C07C69/33 , C12P7/62 , C12P19/44 , C12R1/645
摘要: Novel compounds, called liamocins from Aureobasidium pullulans, having the general structure in Formula 1 are disclosed. where R1 is either COCH3 or H; and R2 is between two to ten O-linked 3,5-dihydroxydecanoate; and R3 can be a polyol (e.g., L- or D-glycerol, L- or D-threitol, L- or D-erythritol, L- or D-arabitol, L- or D-xylitol, L- or D-lyxitol, L- or D-ribitol, L- or D-allitol, L- or D-altritol, L- or D-mannitol, L- or D-iditol, L- or D-gulitol, L- or D-glucitol (also called sorbitol), L- or D-galactitol (also called dulcitol), and L- or D-talitol), 2-amino-D-mannitol, 2N-acetylamino-D-mannitol, L-rhamnitol, or D-fucitol; except when R3 is D-mannitol, R2 is not 2 nor 3 O-linked 3,5-dihydroxydecanoate chains. These liamocins described above in addition to D-mannitol liamocin A1, D-mannitol liamocin A2, D-mannitol liamocin B1, and D-mannitol liamocin B2, alone or in combination with each other, can be used to kill certain bacteria and to treat certain bacterial infections.
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公开(公告)号:US20170367388A1
公开(公告)日:2017-12-28
申请号:US15701171
申请日:2017-09-11
发明人: Frank Derosa , Michael E. Lankin , Andrew T. Lupo
IPC分类号: A23L27/20 , C11D3/20 , C11B9/00 , C07C69/96 , C07C69/708 , C07C69/003 , C07C47/198 , C07C43/15 , C07C43/11 , A61Q19/10 , A61Q13/00 , A61Q11/00 , A61Q5/02 , A61K47/14 , A61K47/08 , A61K8/39 , A61K8/37 , A61K8/33 , A23L2/56 , C11D3/50
CPC分类号: A23L27/2028 , A23L2/56 , A23L27/20 , A23V2002/00 , A61K8/33 , A61K8/37 , A61K8/39 , A61K47/08 , A61K47/14 , A61Q5/02 , A61Q11/00 , A61Q13/00 , A61Q19/10 , C07C43/11 , C07C43/15 , C07C47/198 , C07C69/003 , C07C69/708 , C07C69/96 , C11B9/0015 , C11B9/0019 , C11D3/2068 , C11D3/2072 , C11D3/2093 , C11D3/50
摘要: The present invention is related to substituted butanol derivatives of the formula: wherein R is an unsubstituted or substituted C1-6 straight chain alkyl, an unsubstituted or substituted C3-6 branched chain alkyl, an unsubstituted or substituted C3-6 straight chain alkenyl, an unsubstituted or substituted C3-6 branched chain alkenyl, an unsubstituted or substituted C3-6 cycloalkyl, an unsubstituted or substituted C1-6 alkoxy, nitrile, halo, amino, an unsubstituted or substituted C1-6 alkylamino, an unsubstituted or substituted C1-6 dialkylamino, carboxy-C1-6 alkylamino, carboxy-C1-6 dialkylamino, an unsubstituted or substituted acetoxy, carboxy, an unsubstituted or substituted carboxyethyl, an unsubstituted or substituted C1-6 alkylcarbonyl, an unsubstituted or substituted C1-6 alkylcarboxy, an unsubstituted or substituted C1-6 alkylthio, an unsubstituted or substituted C1-6 alkyloxy, carboxamido, an unsubstituted or substituted C1-6 alkylcarboxamido or an unsubstituted or substituted C1-6 dialkylcarboxamido. Such compounds are useful in flavor or flavor compositions.
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公开(公告)号:US09845443B2
公开(公告)日:2017-12-19
申请号:US14874592
申请日:2015-10-05
申请人: Kedar Ramesh Vaze
发明人: Kedar Ramesh Vaze
IPC分类号: C11B9/00 , C07C31/135 , C07C33/14 , C07C69/003 , C07C69/007
CPC分类号: C11B9/0034 , C07C31/135 , C07C31/1355 , C07C33/14 , C07C69/003 , C07C69/007 , C11B9/003
摘要: A novel odorant of formula (I) wherein each of R1, R2, R3, R3, R5, R6, R7, R8, R9 and R10 are independently selected from H, CH3, and C2H5; X is selected from —CH2OH, —CH2OCOCH3 and —CHO, n is selected from 0 and 1. The dotted line represents double bond or single bond.
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