公开(公告)号：US11382848B2

公开(公告)日：2022-07-12

申请号：US16480331

申请日：2018-01-30

申请人： CHEMCOM S.A. ,  GIVAUDAN S.A.

发明人： Pierre Chatelain ,  Markus Gautschi ,  Thierry Granier ,  Yannick Quesnel ,  Charles Stanley Sell ,  Alex Veithen

IPC分类号： A61K8/34 ,  A61K8/36 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/42 ,  A61Q15/00 ,  C07C33/20 ,  C07C49/217 ,  C07C57/03 ,  C07C69/003 ,  C07C233/09 ,  C07C255/50 ,  C11B9/00

摘要： The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.

公开(公告)号：US11867685B2

公开(公告)日：2024-01-09

申请号：US16770457

申请日：2018-12-05

申请人： CHEMCOM S.A.

发明人： Sandra Huysseune ,  Alex Veithen ,  Yannick Quesnel

IPC分类号： G01N33/50

CPC分类号： G01N33/5008

摘要： The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.

公开(公告)号：US08993526B2

公开(公告)日：2015-03-31

申请号：US13916282

申请日：2013-06-12

申请人： ChemCom S.A.

发明人： Pierre Chatelain ,  Alex Veithen

IPC分类号： A61K38/00 ,  C07K14/72 ,  C07K14/705 ,  G01N33/53 ,  G01N33/567 ,  G01N33/566

CPC分类号： G01N33/566 ,  G01N2500/04

摘要： The invention relates to the identification of carboxylic acids, present in human sweat, as natural ligands of a specific subgroup of seven olfactory receptor (OR) belonging to class 1 within the OR classification. The invention encompasses the use of the interaction of OR polypeptides and carboxylic acids as the basis of screening assays for agents that specifically modulate the activity of the seven ORs of the invention.

摘要翻译： 本发明涉及作为OR分类中属于1类的七个嗅觉受体（OR）的特定亚组的天然配体，存在于人类汗液中的羧酸的鉴定。 本发明包括使用OR多肽和羧酸的相互作用作为特异性调节本发明的七个OR的活性的试剂的筛选测定的基础。

公开(公告)号：US20220378675A1

公开(公告)日：2022-12-01

申请号：US17829538

申请日：2022-06-01

申请人： CHEMCON S.A. ,  GIVAUDAN S.A.

发明人： Pierre Chatelain ,  Markus Gautschi ,  Thierry Granier ,  Yannick Quesnel ,  Charles Stanley Sell ,  Alex Veithen

IPC分类号： A61K8/36 ,  A61K8/34 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/42 ,  A61Q15/00 ,  C07C33/20 ,  C07C49/217 ,  C07C57/03 ,  C07C69/003 ,  C07C233/09 ,  C07C255/50 ,  C11B9/00

摘要： The present invention relates to new malodour-counteracting agents of formula (I) or stereoisomers thereof, particularly useful in blocking the olfactory perception of androstenone, Formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and X have the same meaning as that defined in the claims. The present invention also relates to consumer products comprising said agents. The present invention also relates to the use of said agents to suppress or attenuate undesirable odour, as well as to methods to suppress or attenuate undesirable odour employing said compounds.