专利检索 ap:("CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS") AND inv:"Mark SCHMITT" 第 1 页

1.

发明公开
THERAPEUTIC COMBINATIONS INCLUDING INHIBITORS OF THE P2X4 RECEPTOR FOR TREATING AND PREVENTING PROLIFERATIVE DISORDERS 审中-公开

公开(公告)号：US20240075036A1

公开(公告)日：2024-03-07

申请号：US18280370

申请日：2022-03-18

申请人： CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS

发明人： Florian GRETEN , Mark SCHMITT , Jalaj GUPTA

IPC分类号： A61K31/513 , A61K31/17 , A61K31/198 , A61K31/416 , A61K31/436 , A61K31/4418 , A61K31/522 , A61K31/551 , A61K31/65 , A61K31/675 , A61K31/7076 , A61K31/7084 , A61K38/17 , A61K38/20 , A61K38/45 , A61K45/06 , A61P35/00

CPC分类号： A61K31/513 , A61K31/17 , A61K31/198 , A61K31/416 , A61K31/436 , A61K31/4418 , A61K31/522 , A61K31/551 , A61K31/65 , A61K31/675 , A61K31/7076 , A61K31/7084 , A61K38/1793 , A61K38/2006 , A61K38/45 , A61K45/06 , A61P35/00

摘要： The present invention relates to the use of inhibitors of the P2X4 receptor or inhibitors of the P2X4 receptor signaling pathway in combination with an effective amount of a “cell death inducing chemotherapeutic drug” or “cell death inducing therapy” in the prevention and/or treatment of a solid tumor or metastases thereof in a subject, in particular in colorectal cancer (CRC).