公开(公告)号：US20240018122A1

公开(公告)日：2024-01-18

申请号：US18014764

申请日：2021-07-14

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Daniela PIZZIRANI ,  Matteo BIAGETTI ,  Paolo RONCHI ,  Paolo BRUNO ,  Sara GUARIENTO ,  Barbara BERTANI ,  Daniele PALA ,  Alessio BARILLI

IPC: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D487/04 ,  C07D471/04 ,  C07D405/14

Abstract: The present invention relates to a compound of general formula (I) inhibiting the transforming growth factor-β (TGF-β) type I receptor (ALK5), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of ALK5 signaling pathway in a mammal.