公开(公告)号：US20240190860A1

公开(公告)日：2024-06-13

申请号：US18551942

申请日：2021-03-24

申请人： CHIESI FARMACEUTICI S.p.A.

发明人： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Marta GIULIANI ,  Luca RAVEGLIA ,  Claudia BEATO

IPC分类号： C07D417/14 ,  A61K31/517 ,  C07D401/04 ,  C07D413/14

CPC分类号： C07D417/14 ,  A61K31/517 ,  C07D401/04 ,  C07D413/14

摘要： The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are 8-cyclo-substituted quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20230063121A1

公开(公告)日：2023-03-02

申请号：US17784557

申请日：2020-12-10

申请人： CHIESI FARMACEUTICI S.P.A.

发明人： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Luca RAVEGLIA ,  Marta GIULIANI ,  Claudia BEATO

IPC分类号： C07D417/12 ,  C07D239/94 ,  C07D413/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/14

摘要： The present invention relates to a compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.