公开(公告)号：US20230250093A1

公开(公告)日：2023-08-10

申请号：US18015767

申请日：2021-07-15

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Elisabetta ARMANI ,  Gabriele AMARI ,  Andrea RIZZI ,  Mafalda PAGANO ,  Luca RAVEGLIA ,  Claudia BEATO

IPC: C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D409/04 ,  C07D417/14 ,  C07D249/06 ,  C07D417/04 ,  C07D231/40 ,  C07D333/36

CPC classification number: C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D409/04 ,  C07D417/14 ,  C07D249/06 ,  C07D417/04 ,  C07D231/40 ,  C07D333/36

Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 1 (LPA1), particularly the invention relates to compounds that are Ami do cyclohexane acid derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20240190860A1

公开(公告)日：2024-06-13

申请号：US18551942

申请日：2021-03-24

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Marta GIULIANI ,  Luca RAVEGLIA ,  Claudia BEATO

IPC: C07D417/14 ,  A61K31/517 ,  C07D401/04 ,  C07D413/14

CPC classification number: C07D417/14 ,  A61K31/517 ,  C07D401/04 ,  C07D413/14

Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are 8-cyclo-substituted quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20230061417A1

公开(公告)日：2023-03-02

申请号：US17784551

申请日：2020-12-10

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Luca RAVEGLIA

IPC: C07D495/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are thienopyrimidine derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20230063121A1

公开(公告)日：2023-03-02

申请号：US17784557

申请日：2020-12-10

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Luca RAVEGLIA ,  Marta GIULIANI ,  Claudia BEATO

IPC: C07D417/12 ,  C07D239/94 ,  C07D413/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/14

Abstract: The present invention relates to a compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are quinazoline derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20230043672A1

公开(公告)日：2023-02-09

申请号：US17784539

申请日：2020-12-10

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Gabriele AMARI ,  Elisabetta ARMANI ,  Mafalda PAGANO ,  Luca RAVEGLIA ,  Claudia BEATO

IPC: C07D417/14 ,  C07D417/12

Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 2 (LPA2), particularly the invention relates to compounds that are aromatic amido derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.