公开(公告)号：US20240279240A1

公开(公告)日：2024-08-22

申请号：US18282096

申请日：2022-03-14

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Andrea RIZZI ,  Alberto CUZZOLIN ,  Milan MESIC ,  Rahela ZADRAVEC ,  Dinko ZIHER ,  Ivaylo ELENKOV

IPC: C07D519/00 ,  A61K9/00 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D471/04

CPC classification number: C07D519/00 ,  A61K9/0073 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D471/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.

公开(公告)号：US20240166651A1

公开(公告)日：2024-05-23

申请号：US18282068

申请日：2022-03-14

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Andrea RIZZI ,  Dinko ZIHER ,  Milan MESIC ,  Ivaylo ELENKOV

IPC: C07D487/04 ,  A61K9/00 ,  A61K31/4365 ,  A61K31/519 ,  A61K45/06 ,  C07D495/04

CPC classification number: C07D487/04 ,  A61K9/0073 ,  A61K31/4365 ,  A61K31/519 ,  A61K45/06 ,  C07D495/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2); methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.