公开(公告)号：US20240279240A1

公开(公告)日：2024-08-22

申请号：US18282096

申请日：2022-03-14

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Andrea RIZZI ,  Alberto CUZZOLIN ,  Milan MESIC ,  Rahela ZADRAVEC ,  Dinko ZIHER ,  Ivaylo ELENKOV

IPC: C07D519/00 ,  A61K9/00 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D471/04

CPC classification number: C07D519/00 ,  A61K9/0073 ,  A61K31/497 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D471/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.

公开(公告)号：US20170119753A1

公开(公告)日：2017-05-04

申请号：US15404897

申请日：2017-01-12

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Fabio RANCATI ,  Andrea RIZZI ,  Laura CARZANIGA ,  Ian LINNEY ,  Chris KNIGHT ,  Wolfgang SCHMIDT

IPC: A61K31/4709 ,  A61K31/5386 ,  A61K31/496 ,  A61K9/00 ,  A61K31/4704

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/5386 ,  A61K45/06 ,  C07D215/227 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D453/02 ,  C07D453/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D498/10

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating broncho-obstructive and inflammatory diseases.

公开(公告)号：US20240166651A1

公开(公告)日：2024-05-23

申请号：US18282068

申请日：2022-03-14

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Alessandro ACCETTA ,  Fabio RANCATI ,  Andrea RIZZI ,  Dinko ZIHER ,  Milan MESIC ,  Ivaylo ELENKOV

IPC: C07D487/04 ,  A61K9/00 ,  A61K31/4365 ,  A61K31/519 ,  A61K45/06 ,  C07D495/04

CPC classification number: C07D487/04 ,  A61K9/0073 ,  A61K31/4365 ,  A61K31/519 ,  A61K45/06 ,  C07D495/04

Abstract: The present invention relates to a compounds of general formula (I) inhibiting the JAK family of non-receptor tyrosine protein kinases (JAK1, JAK2, JAK3, and TYK2); methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of the JAK family non-receptor kinases; in particular for the treatment of various inflammatory disease including asthma, COPD and other respiratory diseases.

公开(公告)号：US20150057257A1

公开(公告)日：2015-02-26

申请号：US14537184

申请日：2014-11-10

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Eleonora GHIDINI ,  Andrea RIZZI

IPC: C07J71/00 ,  A61K45/06 ,  A61K31/58

CPC classification number: C07J71/0068 ,  A61K31/58 ,  A61K45/06

Abstract: Anti-inflammatory and antiallergic compounds of the glucocorticosteroid series, according to formula (I) according to formula (I) defined herein are useful for treating diseases of the respiratory tract characterized by airway obstruction.

Abstract translation: 根据本文定义的式（I）的式（I）的糖皮质激素系列的抗炎和抗过敏化合物可用于治疗以气道阻塞为特征的呼吸道疾病。

公开(公告)号：US20240391936A1

公开(公告)日：2024-11-28

申请号：US18283861

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Andrea RIZZI ,  Nicoió IOTTI ,  Fabio RANCATI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  David Edward CLARK ,  Toby Matthew Grover MULLINS ,  Keith Christopher KNIGHT ,  Ben Paul WHITTAKER ,  Stefano LEVANTO

IPC: C07D519/00 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240217967A1

公开(公告)日：2024-07-04

申请号：US18283851

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Nicolò IOTTI ,  Keith Christopher KNIGHT ,  Toby Matthew Grover MULLINS ,  Anna KARAWAJCZYK ,  Ben Paul WHITTAKER

IPC: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

CPC classification number: C07D471/04 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  C07D401/14 ,  C07D403/14 ,  C07D417/04 ,  C07D487/04

Abstract: The present invention relates to compounds of general formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20230250093A1

公开(公告)日：2023-08-10

申请号：US18015767

申请日：2021-07-15

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Elisabetta ARMANI ,  Gabriele AMARI ,  Andrea RIZZI ,  Mafalda PAGANO ,  Luca RAVEGLIA ,  Claudia BEATO

IPC: C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D409/04 ,  C07D417/14 ,  C07D249/06 ,  C07D417/04 ,  C07D231/40 ,  C07D333/36

CPC classification number: C07D413/04 ,  C07D401/04 ,  C07D413/14 ,  C07D409/04 ,  C07D417/14 ,  C07D249/06 ,  C07D417/04 ,  C07D231/40 ,  C07D333/36

Abstract: The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 1 (LPA1), particularly the invention relates to compounds that are Ami do cyclohexane acid derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of LPA receptors, in particular fibrosis.

公开(公告)号：US20160346271A1

公开(公告)日：2016-12-01

申请号：US15168466

申请日：2016-05-31

Applicant: CHIESI FARMACEUTICI S.p.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Ian LINNEY ,  Wolfgang SCHMIDT ,  Michael BARNES ,  Chris KNIGHT

IPC: A61K31/4709 ,  A61M16/14 ,  A61M15/00 ,  C07D453/02 ,  A61K9/00

CPC classification number: A61K31/4709 ,  A61K9/0073 ,  A61M15/009 ,  A61M16/14 ,  A61M2202/064 ,  C07D453/02

Abstract: Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating diseases of the respiratory tract.

Abstract translation: 式I定义的化合物既作为毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂，也可用于治疗呼吸道疾病。

公开(公告)号：US20240425482A1

公开(公告)日：2024-12-26

申请号：US18702454

申请日：2022-10-17

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Eleonora GHIDINI ,  Nicolò IOTTI ,  Roberta MAZZUCATO ,  Stefano LEVANTO ,  Ben Paul WHITTAKER

IPC: C07D401/14 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/14 ,  C07D487/10

Abstract: The present invention relates to compounds of formula (I) inhibiting Discoidin Domain Receptors (DDR inhibitors), methods of preparing such compounds, intermediate compounds useful in such preparations, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful for instance in the treatment of many disorders associated with DDR mechanisms.

公开(公告)号：US20240190847A1

公开(公告)日：2024-06-13

申请号：US18283855

申请日：2022-03-25

Applicant: CHIESI FARMACEUTICI S.P.A.

Inventor： Laura CARZANIGA ,  Fabio RANCATI ,  Andrea RIZZI ,  Anna KARAWAJCZYK ,  Barbara Karolina WOLEK ,  Toby Matthew Grover MULLINS

IPC: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D401/14

Abstract: The present invention relates to compounds of general formula (I) inhibiting DDR1 and DDR2. Particularly, the invention relates to compounds that are indoline derivatives, pharmaceutical compositions containing them and therapeutic use thereof. The compounds of the invention may be useful in the treatment of diseases or conditions associated with a dysregulation of DDRs, in particular fibrosis.