公开(公告)号：US09683995B2

公开(公告)日：2017-06-20

申请号：US14701810

申请日：2015-05-01

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION

Inventor： Leonard I. Zon ,  Craig Ceol ,  Yariv J. Houvras

IPC: G01N33/574 ,  A61K39/395 ,  C07K16/40 ,  C12N15/11 ,  C12Q1/68 ,  C12N15/113

CPC classification number: G01N33/5743 ,  A61K39/39558 ,  C07K16/40 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y201/01043 ,  G01N33/574 ,  G01N2333/91011 ,  G01N2333/91017

Abstract: Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.

公开(公告)号：US20150293099A1

公开(公告)日：2015-10-15

申请号：US14701810

申请日：2015-05-01

Applicant: CHILDREN'S MEDICAL CENTER CORPORATION

Inventor： Leonard I. Zon ,  Craig Ceol ,  Yariv J. Houvras

IPC: G01N33/574 ,  C12Q1/68 ,  A61K39/395

CPC classification number: G01N33/5743 ,  A61K39/39558 ,  C07K16/40 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Y201/01043 ,  G01N33/574 ,  G01N2333/91011 ,  G01N2333/91017

Abstract: Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.

Abstract translation: 本文提供了通过确定生物样品中SETDB1的表达水平来诊断癌症的方法。 本文还提供了通过向有需要的受试者施用SETDB1抑制剂来治疗癌症的方法。