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公开(公告)号：US10159697B2
公开(公告)日：2018-12-25
申请号：US15651416
申请日：2017-07-17
Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Leonard I. Zon , Pulin Li
IPC: A61K35/28 , A61K31/19 , A61K31/221 , A61K31/255 , C12N5/0789 , A61K31/095 , A61K31/21 , A61K35/12
Abstract: Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
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公开(公告)号：US20150293099A1
公开(公告)日：2015-10-15
申请号：US14701810
申请日：2015-05-01
Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Leonard I. Zon , Craig Ceol , Yariv J. Houvras
IPC: G01N33/574 , C12Q1/68 , A61K39/395
CPC classification number: G01N33/5743 , A61K39/39558 , C07K16/40 , C12N15/1137 , C12N2310/14 , C12Q1/6886 , C12Q2600/158 , C12Y201/01043 , G01N33/574 , G01N2333/91011 , G01N2333/91017
Abstract: Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an inhibitor of SETDB1 to a subject in need thereof.
Abstract translation: 本文提供了通过确定生物样品中SETDB1的表达水平来诊断癌症的方法。 本文还提供了通过向有需要的受试者施用SETDB1抑制剂来治疗癌症的方法。
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公开(公告)号：US20150246075A1
公开(公告)日：2015-09-03
申请号：US14706560
申请日：2015-05-07
Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Leonard I. Zon , Pulin Li
IPC: A61K35/28 , A61K31/19 , A61K31/336 , A61K31/662 , A61K45/06 , A61K31/23
CPC classification number: A61K35/28 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/23 , A61K31/336 , A61K31/662 , A61K45/06 , A61K2035/124
Abstract: Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
Abstract translation: 本文描述的是使用使用造血细胞移植的斑马鱼模型鉴定的化合物来增强造血干细胞和祖细胞移植物的方法。 该化合物可用于在移植细胞之前离体处理造血干细胞。 或者，可将化合物给予经历细胞移植的个体。
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4.发明申请公开(公告)号：US20130209424A1
公开(公告)日：2013-08-15
申请号：US13837265
申请日：2013-03-15
Inventor： Leonard I. Zon , Trista E. North , Wolfram Goessling
CPC classification number: A61K35/14 , A61K31/575 , A61K35/28 , A61K35/50 , A61K45/06 , A61P43/00 , C12N5/0647 , C12N2501/02
Abstract: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Abstract translation: 本发明提供了通过使用HCS调节剂调节造血干细胞群体的组合物和方法，所述HCS调节剂是根据特定适应症所希望的增加HSC数量或降低HSC数量的药剂。 例如，发现增加HSC数量的HSC调节剂包括前列腺素E2（PGE2）和刺激PGE2途径的试剂。 相反，防止PGE2合成的HSC调节剂降低HSC数。 HCS调节剂可以在体外，体内或体外使用。
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公开(公告)号：US11944625B2
公开(公告)日：2024-04-02
申请号：US17175079
申请日：2021-02-12
Inventor： James Bradner , Jun Qi , Dennis Buckley , Leonard I. Zon , Elizabeth Macari
IPC: A61K31/517 , A61K31/225 , A61K31/403 , A61K31/506 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/7048 , A61K45/06 , A61P7/06
CPC classification number: A61K31/517 , A61K31/225 , A61K31/403 , A61K31/506 , A61K31/519 , A61K31/5415 , A61K31/55 , A61K31/7048 , A61P7/06 , A61K45/06
Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.
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Patent Agency Ranking
公开(公告)号：US11065258B2
公开(公告)日：2021-07-20
申请号：US16538293
申请日：2019-08-12
Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Leonard I. Zon , Alison M. Taylor
IPC: A61K31/553 , A61K31/495 , A61K31/4965 , A61K31/54 , A61K31/5415 , A61K31/145 , A61K31/4184 , A61K31/4375 , A61K31/4418
Abstract: The present invention relates generally to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to methods for the use of calmodulin inhibitors and calcium channel blockers for treatment of ribosomal disorders and ribosomopathy, e.g. Diamond Blackfan anemia (DBA).
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公开(公告)号：US20170333483A1
公开(公告)日：2017-11-23
申请号：US15651416
申请日：2017-07-17
Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Leonard I. Zon , Pulin Li
IPC: A61K35/28 , A61K31/19 , C12N5/0789 , A61K31/255 , A61K31/221 , A61K31/21 , A61K31/095 , A61K35/12
CPC classification number: A61K35/28 , A61K31/095 , A61K31/19 , A61K31/21 , A61K31/221 , A61K31/255 , A61K2035/124 , C12N5/0647 , C12N2500/36 , C12N2501/999
Abstract: Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
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公开(公告)号：US09737567B2
公开(公告)日：2017-08-22
申请号：US14691870
申请日：2015-04-21
Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
Inventor： Leonard I. Zon , Pulin Li
IPC: A01N63/00 , A61K35/28 , A61K31/19 , A61K31/221 , A61K31/255 , C12N5/0789 , A61K31/095 , A61K31/21 , A61K35/12
CPC classification number: A61K35/28 , A61K31/095 , A61K31/19 , A61K31/21 , A61K31/221 , A61K31/255 , A61K2035/124 , C12N5/0647 , C12N2500/36 , C12N2501/999
Abstract: Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using farnesyl compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplantation of the cells. Alternatively, the compounds can be administered to an individual undergoing cell transplantation.
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公开(公告)号：US10278990B2
公开(公告)日：2019-05-07
申请号：US13836794
申请日：2013-03-15
Inventor： Leonard I. Zon , Trista E. North , Wolfram Goessling
IPC: A61K35/14 , C12N5/0789 , A61K45/06 , A61K35/28 , A61K31/575 , A61K35/50 , A61P43/00
Abstract: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
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公开(公告)号：US10272110B2
公开(公告)日：2019-04-30
申请号：US13838002
申请日：2013-03-15
Inventor： Leonard I. Zon , Trista E. North , Wolfram Goessling
IPC: A61K35/14 , C12N5/0789 , A61K35/28 , A61K45/06 , A61K31/575 , A61K35/50 , A61P43/00
Abstract: The present invention provides for compositions and methods for modulating hematopoetic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
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