专利检索 ap:("CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER") AND inv:"Pan Zheng" 第 1 页

1.

发明授权
CD80 and CD86 binding protein compositions and uses thereof 有权

公开(公告)号：US11261233B2

公开(公告)日：2022-03-01

申请号：US16333888

申请日：2017-09-19

申请人： ONCOC4, INC. , CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Yang Liu , Pan Zheng , Martin Devenport , Wei Wu , Xuexiang Du , Mingyue Liu , Fei Tang

IPC分类号： C07K14/705 , C07K16/46 , A61K38/00 , A61P37/06 , A61P35/00 , C07K16/28 , A61K39/395 , C07K14/00 , A61K39/00

摘要： This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.

2.

发明授权
Echinomycin formulation, method of making and method of use thereof 有权

公开(公告)号：US11116726B2

公开(公告)日：2021-09-14

申请号：US15774217

申请日：2016-11-09

申请人： CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Yang Liu , Yin Wang , Yan Liu , Christopher Bailey , Pan Zheng

IPC分类号： A61K9/127 , A61K38/16 , A61K47/69 , A61K35/74 , A61P37/02 , A61P35/02

摘要： A liposomal drug formulation for treating a disease in a patient characterized by overexpression of HIF-1α and/or HIF-2α includes a plurality of liposomes in a pharmaceutically acceptable carrier. The liposomes encapsulate echinomycin and are made from a peglyated phospholipid, a neutral phosphoglyceride, and a sterol. The PEGylated liposomes may be used to treat proliferative diseases, leukemia, cancer, autoimmune diseases and graft-versus-host disease.

3.

发明申请
ANTI-CD24 COMPOSITIONS AND USES THEREOF 有权

公开(公告)号：US20210214458A1

公开(公告)日：2021-07-15

申请号：US17055248

申请日：2019-05-13

申请人： ONCOIMMUNE, INC. , CHILDREN'S RESEARCH INSTITUTE, CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Yang Liu , Pan Zheng , Rhonda Flores , Hung-Yen Chou , Zhihong Xue , Peiying Ye , Martin Devenport

IPC分类号： C07K16/28 , A61P35/00

摘要： Provided herein are anti-CD24 antibodies that selectively bind human CD24 expressed in cancer cells, but not human CD24 expressed in non-cancerous cells, and the use of such antibodies in cancer therapy.

4.

发明申请
METHODS OF SELECTING AND DESIGNING SAFER AND MORE EFFECTIVE ANTI-CTLA-4 ANTIBODIES FOR CANCER THERAPY 有权

公开(公告)号：US20210047410A1

公开(公告)日：2021-02-18

申请号：US16967065

申请日：2019-01-29

申请人： oncolmmune, Inc. , Children's Research Institute, Children's National Medical Center

发明人： Yang Liu , Pan Zheng , Fei Tang , Mingyue Liu , Martin Devenport , Xuexiang Du , Yan Zhang

IPC分类号： C07K16/28 , A61P35/00 , C12N5/071 , C12N5/0783 , G01N33/58

摘要： The present invention relates to compositions of anti-CTLA-4 antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for the reduction of autoimmune side effects compared to other immunotherapeutic agents.

5.

发明申请
Targeting CD24-Siglec Interactions for Treating Subjects with Prediabetes or Diabetes 有权

公开(公告)号：US20220000974A1

公开(公告)日：2022-01-06

申请号：US17428784

申请日：2020-02-05

申请人： Oncolmmune, Inc. , Children's Research Institute, Children's National Medical Center

发明人： Yang Liu , Pan Zheng , Xu Wang , Martin Devenport

IPC分类号： A61K38/17 , C07K14/705 , A61P3/06 , A61P3/10

摘要： Provided herein are methods and compositions for lowering low-density lipoprotein cholesterol or glucose levels, and for treating subjects with prediabetes or diabetes by targeting CD24-Siglec interactions.