公开(公告)号：US20230165833A1

公开(公告)日：2023-06-01

申请号：US16967401

申请日：2019-09-16

申请人： CHINA PHARMACEUTICAL UNIVERSITY

发明人： Haopeng SUN ,  Hongyu YANG ,  Tingkai CHEN ,  Yao CHEN ,  Feng FENG ,  Chenxi DU

IPC分类号： A61K31/381 ,  A61K31/40 ,  A61K31/341 ,  A61K31/4402 ,  A61K31/426 ,  A61K31/4164 ,  A61K31/167 ,  A61K31/24 ,  A61K31/277 ,  A61P25/28 ,  A61K31/195

CPC分类号： A61K31/381 ,  A61K31/24 ,  A61K31/40 ,  A61K31/167 ,  A61K31/195 ,  A61K31/277 ,  A61K31/341 ,  A61K31/426 ,  A61K31/4164 ,  A61K31/4402 ,  A61P25/28

摘要： The present invention discloses a selective butyrylcholinesterase inhibitor having a general formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and use thereof. The treatment efficacy of Alzheimer’s disease, especially moderate to severe Alzheimer’s disease, is tested through butyrylcholinesterase inhibitory activity, selectivity screening and toxicity to nerve cells as a carrier, and it is found that it has good target activity in vitro, extremely high selectivity and drug safety, can be used as a lead substance for further development of the treatment of Alzheimer’s disease by selectively inhibiting butyrylcholinesterase.

公开(公告)号：US20240280493A1

公开(公告)日：2024-08-22

申请号：US18570741

申请日：2023-02-09

申请人： CHINA PHARMACEUTICAL UNIVERSITY

发明人： Wenyuan LIU ,  Lingfei HAN ,  Feng FENG

IPC分类号： G01N21/65 ,  B22F1/054 ,  B22F1/102 ,  B22F1/145 ,  B22F9/24 ,  G01N33/50 ,  G01N33/543

CPC分类号： G01N21/658 ,  B22F1/054 ,  B22F1/102 ,  B22F1/145 ,  B22F9/24 ,  G01N33/5067 ,  G01N33/54346 ,  B22F2301/255 ,  B22F2304/054 ,  B22F2998/10 ,  B22F2999/00

摘要： A cell-based sensor based on surface-enhanced Raman scattering and an application thereof. The cell-based sensor is established by guiding a surface-enhanced Raman scattering probe into a human liver cell line; the surface-enhanced Raman scattering probe is prepared by using a gold nanoparticle as a testing substrate, a gene damage effector molecule antibody as a recognition unit, a Raman molecule as a reporting unit, SH-PEG-NH2 as a stable chain and a cell-penetrating peptide as an auxiliary penetration unit; and the cell-based sensor is exposed to various drug impurities, a Raman signal is detected, and a type and a level of the genotoxic impurities are assessed.