公开(公告)号：US20210153535A1

公开(公告)日：2021-05-27

申请号：US17051653

申请日：2019-05-01

Applicant: Chr. Hansen A/S

Inventor： Brynjulf MORTENSEN ,  Anders DAMHOLT ,  Anja WELLEJUS ,  Vibeke WESTPHAL STENNICKE ,  Johan E. T. VAN HYCKLAMA VLIEG

IPC: A23L33/135 ,  A61K35/745 ,  A61K45/06 ,  A61P1/00

Abstract: The present invention relates to Bifidobacterium breve deposited as DSM 32356 and compositions comprising said strain. The composition may further comprise at least one other bacterial strain and/or at least one compound which may be an NSAID such as acetylsalicylic acid (aspirin). In a presently preferred embodiment the invention relates to Bifidobacterium breve deposited as DSM 32356 for use in the support of the defense against intestinal tissue damage such as intestinal mucosal breaks or lesions e.g. in connection with NSAID administration such as in connection with administration of acetylsalicylic acid (aspirin). The invention further provides a method of supporting the defense against intestinal tissue damage, the method comprising administering the Bifidobacterium breve strain deposited as DSM 32356 to a subject in need thereof, e.g. to a subject in need of NSAID treatment.

公开(公告)号：US20170252382A1

公开(公告)日：2017-09-07

申请号：US15504913

申请日：2015-08-28

Applicant: CHR. HANSEN A/S

Inventor： THOMAS DYRMANN LESER ,  Dorte MYLING-PETERSEN ,  Jeffrey Earl CHRISTENSEN ,  Anja WELLEJUS ,  Elke BROCKMANN

IPC: A61K35/745 ,  C12R1/01 ,  A61K47/26

CPC classification number: A61K35/745 ,  A61K47/26 ,  C12R1/01

Abstract: The present invention relates to novel isolated strains of Bifidobacterium adolescentis which are capable of i) increasing the trans-epithelial electrical resistance (TER) of a Caco-2 cell monolayer after 10 h treatment to more than 120% of TER at treatment start, ii) inducing secretion of >200 pg/ml of IL-10, and/or iii) inducing an IL-10:IL-12 ratio>1 when co-incubated with human PBMC derived dendritic cells. The strains may have one, two or all three of these capabilities. The present invention relates to the use of these novel strains for the in prevention, alleviation of symptoms, and treatment of diseases or conditions with an underlying impaired intestinal barrier function and pro-inflammatory activation of the mucosa. More specifically, the present invention relates to se of an isolated strain according to the invention for the prevention, alleviation of symptoms, or treatment of intestinal inflammatory conditions such as IBD and IBS, liver diseases such as NAFLD, NASH, cirrhosis, and alcohol-related liver disease, metabolic disorders such as metabolic syndrome, insulin resistance, type 2 diabetes, obesity, cardiovascular atherosclerosis, autoimmune diseases, such as celiac disease, type 1 diabetes, multiple sclerosis and rheumatoid arthritis, and mental conditions such as major depressive disorders, a mood disorder, a cognitive chronic fatigue syndrome, and anxiety.