公开(公告)号：US20190231930A1

公开(公告)日：2019-08-01

申请号：US16379121

申请日：2019-04-09

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： LESLIE SIERAD ,  ELIZA LAINE SHAW ,  GEORGE FERCANA ,  DAN SIMIONESCU

IPC: A61L27/36

CPC classification number: A61L27/3687 ,  A61F2/2415 ,  A61L27/3604 ,  A61L27/3625 ,  A61L27/3691 ,  A61L2430/20 ,  A61L2430/40

Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.