公开(公告)号：US20210246411A1

公开(公告)日：2021-08-12

申请号：US17244447

申请日：2021-04-29

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： LESLIE SIERAD ,  CHRISTOPHER DELANEY ,  RICHARD PASCAL, III ,  DAN SIMIONESCU ,  AGNETA SIMIONESCU

IPC: C12M1/34 ,  C12M1/00 ,  C12M1/42 ,  C12M3/00

Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).

公开(公告)号：US20190231930A1

公开(公告)日：2019-08-01

申请号：US16379121

申请日：2019-04-09

Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION

Inventor： LESLIE SIERAD ,  ELIZA LAINE SHAW ,  GEORGE FERCANA ,  DAN SIMIONESCU

IPC: A61L27/36

CPC classification number: A61L27/3687 ,  A61F2/2415 ,  A61L27/3604 ,  A61L27/3625 ,  A61L27/3691 ,  A61L2430/20 ,  A61L2430/40

Abstract: Systems and methods that establish a pressure differential across a tissue wall to encourage complete decellularization of the wall are described. The methods can be utilized for decellularization of blood vessel tissue including heart valves and surrounding tissues. The methods and systems can essentially completely decellularize the treated tissue segments. Systems can be utilized to decellularize one or multiple tissue segments at a single time.