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公开(公告)号：US20230191283A1
公开(公告)日：2023-06-22
申请号：US18108828
申请日：2023-02-13
Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION
Inventor： R. KENNETH MARCUS , TERRI F. BRUCE , LEI WANG , SISI HUANG , TYLER Y. SLONECKI , RHONDA REIGERS POWELL
CPC classification number: B01D15/327 , C07K14/47 , C12N9/00 , C12N15/10 , C12N15/1017 , G01N1/405 , G01N33/5005 , A61K35/68
Abstract: A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)
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公开(公告)号：US20190240594A1
公开(公告)日：2019-08-08
申请号：US16267579
申请日：2019-02-05
Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION
Inventor： R. KENNETH MARCUS , TERRI F. BRUCE , LEI WANG , SISI HUANG , TYLER Y. SLONECKI , RHONDA REIGERS POWELL
CPC classification number: B01D15/327 , A61K35/68 , B01J20/262 , B01J20/28023 , B01J20/285 , B01J20/286 , B01J2220/54 , C07K14/47 , G01N1/405 , G01N33/5005
Abstract: A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)
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