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公开(公告)号：US20180195053A1
公开(公告)日：2018-07-12
申请号：US15903264
申请日：2018-02-23
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US20210002618A1
公开(公告)日：2021-01-07
申请号：US16995444
申请日：2020-08-17
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US20180371431A1
公开(公告)日：2018-12-27
申请号：US16113684
申请日：2018-08-27
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US09611462B2
公开(公告)日：2017-04-04
申请号：US14366761
申请日：2012-12-18
申请人： Codexis, Inc.
发明人： Ee Lui Ang , Ellen D. Eberhard , Xiyun Zhang , Wei Zhang , Jing Tian , Derek J. Smith , Vesna Mitchell
CPC分类号： C12N9/2437 , C12P19/02 , C12P19/14 , C12Y302/01004
摘要： The present invention provides endoglucanase 1b (EG1b) variants suitable for use in saccharification reactions. The present application further provides genetically modified fungal organisms that produce EG1b variants, as well as enzyme mixtures exhibiting enhanced hydrolysis of cellulosic material to fermentable sugars, enzyme mixtures produced by the genetically modified fungal organisms, and methods for producing fermentable sugars from cellulose using such enzyme mixtures.
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公开(公告)号：US11384343B2
公开(公告)日：2022-07-12
申请号：US17184427
申请日：2021-02-24
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US10961517B2
公开(公告)日：2021-03-30
申请号：US16995444
申请日：2020-08-17
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US09938509B2
公开(公告)日：2018-04-10
申请号：US15698319
申请日：2017-09-07
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
IPC分类号： C12N9/02 , C12N1/21 , C12N5/10 , C12N15/70 , C12N15/74 , C12N15/79 , C12N15/53 , C12P11/00 , C12P13/02 , C12P41/00
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US09528095B2
公开(公告)日：2016-12-27
申请号：US15159578
申请日：2016-05-19
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
CPC分类号： C12N9/0073 , C12P11/00 , C12P13/02 , C12P41/002 , C12Y114/13022 , Y02P20/52
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US20210198638A1
公开(公告)日：2021-07-01
申请号：US17184427
申请日：2021-02-24
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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公开(公告)号：US10781429B2
公开(公告)日：2020-09-22
申请号：US16716239
申请日：2019-12-16
申请人： CODEXIS, INC.
发明人： Ee Lui Ang , Oscar Alvizo , Behnaz Behrouzian , Michael D. Clay , Steven J. Collier , Ellen D. Eberhard , Fu Fan , Shiwei Song , Derek J. Smith , Magnus Widegren , Robert Wilson , Junye Xu , Jun Zhu
摘要： The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.
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