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公开(公告)号：US20230272354A1
公开(公告)日：2023-08-31
申请号：US18180711
申请日：2023-03-08
申请人： Codexis, Inc.
发明人： Jovana Nazor , Robert Osborne , Jack Liang , Jonathan Vroom , Xiyun Zhang , David Entwistle , Rama Voladri , Ravi David Garcia , Jeffrey C. Moore , Shane Grosser , Birgit Kosjek , Matthew Truppo
CPC分类号： C12N9/0071 , C12P17/12 , C12Y114/11002 , C12Y114/11
摘要： The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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公开(公告)号：US20210238565A1
公开(公告)日：2021-08-05
申请号：US17236928
申请日：2021-04-21
申请人： Codexis, Inc.
发明人： Rama Voladri , David Entwistle , Christopher Michael Micklitsch , Vesna Mitchell , Nikki Dellas , Xiyun Zhang , Antoinette Sero , Brent Dorr , Douglas E. Fuerst
IPC分类号： C12N9/18
摘要： The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in amidation reactions.
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公开(公告)号：US20210230564A1
公开(公告)日：2021-07-29
申请号：US17224008
申请日：2021-04-06
申请人： Codexis Inc.
发明人： Ish K. Dhawan , Gregory Miller , Xiyun Zhang
摘要： The present disclosure provides engineered transaminase enzymes having improved properties as compared to a naturally occurring wild-type transaminase enzyme. Also provided are polynucleotides encoding the engineered transaminase enzymes, host cells capable of expressing the engineered transaminase enzymes, and methods of using the engineered transaminase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US20200231959A1
公开(公告)日：2020-07-23
申请号：US16831698
申请日：2020-03-26
申请人： Codexis, Inc.
IPC分类号： C12N9/88
摘要： The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
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公开(公告)号：US10704030B2
公开(公告)日：2020-07-07
申请号：US16562673
申请日：2019-09-06
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US20200032236A1
公开(公告)日：2020-01-30
申请号：US16653061
申请日：2019-10-15
申请人： Codexis, Inc.
IPC分类号： C12N9/88
摘要： The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
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公开(公告)号：US20200032234A1
公开(公告)日：2020-01-30
申请号：US16601278
申请日：2019-10-14
申请人： Codexis, Inc.
IPC分类号： C12N9/88
摘要： The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
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公开(公告)号：US20200032233A1
公开(公告)日：2020-01-30
申请号：US16601173
申请日：2019-10-14
申请人： Codexis, Inc.
IPC分类号： C12N9/88
摘要： The present invention provides engineered phenylalanine ammonia-lyase (PAL) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered phenylalanine ammonia-lyase (PAL) polypeptides.
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公开(公告)号：US20200002685A1
公开(公告)日：2020-01-02
申请号：US16562673
申请日：2019-09-06
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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公开(公告)号：US10450550B2
公开(公告)日：2019-10-22
申请号：US16152709
申请日：2018-10-05
申请人： Codexis, Inc.
发明人： Robert Osborne , Vesna Mitchell , Khin Yu Naing Htwe , Xiyun Zhang , Erika M. Milczek , Jeffrey C. Moore
摘要： The present invention provides improved P450-BM3 variants with improved activity. In some embodiments, the P450-BM3 variants exhibit improved activity over a wide range of substrates.
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