公开(公告)号：US11744901B2

公开(公告)日：2023-09-05

申请号：US16478338

申请日：2018-01-29

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE

Inventor： Piergiuseppe De Berardinis ,  Rossella Sartorius

IPC: A61K47/69 ,  A61P35/00 ,  A61K39/39 ,  C07K14/52 ,  C07K14/77 ,  C07K16/28 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K47/6901 ,  A61K39/39 ,  A61P35/00 ,  C07K14/521 ,  C07K14/77 ,  C07K16/2851 ,  C12N7/00 ,  A61K2039/55572 ,  A61K2039/585 ,  C07K2317/622 ,  C07K2317/77 ,  C07K2319/33 ,  C07K2319/42 ,  C07K2319/735 ,  C07K2319/74 ,  C12N2795/14122 ,  C12N2795/14132 ,  C12N2795/14145

Abstract: The present invention relates to pharmaceutical compositions containing lipid-bacteriophage conjugates, wherein the bacteriophage:lipid ratio is in the range of 3:1 to 100:1 and wherein the lipid is an immunologically active lipid and the bacteriophage is a filamentous bacteriophage, and uses thereof. Preferably, the bacteriophage is engineered to stimulate an immune response and/or bind to a target cell.