公开(公告)号：US09056899B2

公开(公告)日：2015-06-16

申请号：US12812212

申请日：2009-01-12

申请人： James J Collins ,  Timothy Kuan-Ta Lu

发明人： James J Collins ,  Timothy Kuan-Ta Lu

IPC分类号： A01N63/00 ,  C12N7/01 ,  C07K14/005 ,  A61K35/76 ,  C12N15/113

CPC分类号： C07K14/005 ,  A61K35/76 ,  C12N15/113 ,  C12N2320/32 ,  C12N2330/30 ,  C12N2795/14122 ,  C12N2795/14132

摘要： The present invention relates to the treatment and prevention of bacteria and bacterial infections. In particular, the present invention relates to engineered bacteriophages used in combination with antimicrobial agents to potentiate the antimicrobial effect and bacterial killing by the antimicrobial agent. The present invention generally relates to methods and compositions comprising engineered bacteriophages and antimicrobial agents for the treatment of bacteria, and more particularly to bacteriophages comprising agents that inhibit antibiotic resistance genes and/or cell survival genes, and/or bacteriophages comprising repressors of SOS response genes or inhibitors of antimicrobial defense genes and/or expressing an agent which increases the sensitivity of bacteria to an antimicrobial agent in combination with at least one antimicrobial agent, and their use thereof.

摘要翻译： 本发明涉及细菌和细菌感染的治疗和预防。 特别地，本发明涉及与抗微生物剂组合使用的工程化噬菌体，以增强抗微生物效果和抗微生物剂的细菌杀伤作用。 本发明一般涉及包含工程化噬菌体和用于治疗细菌的抗微生物剂的方法和组合物，更具体地涉及包含抑制抗生素抗性基因和/或细胞存活基因的试剂和/或包含SOS应答基因阻遏物的噬菌体的噬菌体 或抗微生物防御基因的抑制剂和/或表达增加细菌对抗微生物剂与至少一种抗微生物剂的敏感性的试剂及其用途。

公开(公告)号：US20150110745A1

公开(公告)日：2015-04-23

申请号：US14384473

申请日：2013-03-15

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Beka Solomon ,  Eyal Dor-On

IPC分类号： A61K35/76 ,  C12N7/00

CPC分类号： A61K35/76 ,  C12N2795/14132 ,  C12N2795/14171 ,  C12N2810/10 ,  C12N2810/40 ,  Y02A50/473

摘要： The invention relates to a filamentous bacteriophage, carrying bacterial Lipopolysaccharide (LPS) endotoxin on its surface, for use in treating cancer and in inhibiting angiogenesis, and in a different context, for use in promoting angiogenesis in diseases or conditions in which there is insufficient angiogenesis.

摘要翻译： 本发明涉及一种丝状噬菌体，其表面携带细菌脂多糖（LPS）内毒素，用于治疗癌症和抑制血管生成，并且在不同的情况下，用于促进血管生成不足的疾病或病症中的血管生成 。

公开(公告)号：US20180305703A1

公开(公告)日：2018-10-25

申请号：US15924045

申请日：2018-03-16

申请人： Trustees of Boston University ,  Massachusetts Institute of Technology

发明人： Timothy Kuan-Ta Lu ,  Robert James Citorik ,  James Collins ,  Russell-John Krom

IPC分类号： C12N15/74 ,  C12N15/70 ,  C12N7/00

CPC分类号： C12N15/74 ,  C12N7/00 ,  C12N15/70 ,  C12N2795/14132 ,  C12N2795/14143 ,  C12N2795/14171 ,  C12N2830/55

摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

公开(公告)号：US20180155721A1

公开(公告)日：2018-06-07

申请号：US15795510

申请日：2017-10-27

申请人： Massachusetts Institute of Technology

发明人： Timothy Kuan-Ta Lu ,  Sebastien Lemire ,  Andrew C. Yang ,  Kevin M. Yehl

IPC分类号： C12N15/113 ,  C07K14/005 ,  A61P31/04

CPC分类号： C12N15/113 ,  A61P31/04 ,  C07K14/005 ,  C12N2320/32 ,  C12N2330/30 ,  C12N2795/00021 ,  C12N2795/00032 ,  C12N2795/14122 ,  C12N2795/14132 ,  G01N33/56916

摘要： Disclosed herein are novel synthetic bacteriophages and bacteriophage compositions, methods of production thereof, and therapeutic uses thereof.

公开(公告)号：US20180105801A1

公开(公告)日：2018-04-19

申请号：US15321942

申请日：2015-06-24

申请人： AUXERGEN, INC.

发明人： Ting-Yu YEH

IPC分类号： C12N7/00 ,  A01N63/02 ,  C12N15/86

CPC分类号： C12N7/00 ,  A01N63/02 ,  C12N15/86 ,  C12N2795/14131 ,  C12N2795/14132 ,  C12N2795/14143 ,  C12N2795/14152 ,  C12N2795/14162

摘要： The present invention describes applications and methods (1) to use bacteriophage Cf and its variants to prevent and treat the citrus canker pathogen, Xanthomonas citri subsp. citri; (2) to engineer recombinant Cf phages that the infectivity is controllable without being harmful to the rest of environment; (3) to engineer and produce recombinant Cf phages with longer storage shelf life; (4) to use Cf phage as a vector for the introduction and insertion of foreign genetic material into Xanthomonas citri subsp. citri. genome; (5) to use and engineer Xp12 and Xf bacteriophages to inhibit Xanthomonas oryzae pv. oryzae, the causal agent of the rice blight disease.

公开(公告)号：US09957511B2

公开(公告)日：2018-05-01

申请号：US14320965

申请日：2014-07-01

申请人： Massachusetts Institute of Technology ,  Trustees of Boston University

发明人： Timothy Kuan-Ta Lu ,  Robert James Citorik ,  James Collins ,  Russell-John Krom

IPC分类号： C12N7/00 ,  C12N15/74 ,  C12N15/70

CPC分类号： C12N15/74 ,  C12N7/00 ,  C12N15/70 ,  C12N2795/14132 ,  C12N2795/14143 ,  C12N2795/14171 ,  C12N2830/55

摘要： Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

公开(公告)号：US20130177533A1

公开(公告)日：2013-07-11

申请号：US13721468

申请日：2012-12-20

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Beka SOLOMON ,  Orna GOREN

IPC分类号： A61K35/76

CPC分类号： A61K35/76 ,  C12N2795/14132 ,  C12N2795/14171 ,  Y10S514/879

摘要： Filamentous bacteriophage which does not display an antibody or a non-filamentous bacteriophage antigen on its surface is used to inhibit or treat brain inflammation associated with amyloid deposits and/or involving activated microglia, to inhibit the formation of amyloid deposits, and to disaggregate pre-formed amyloid deposits.

公开(公告)号：US07867487B2

公开(公告)日：2011-01-11

申请号：US11815294

申请日：2006-01-31

申请人： Beka Solomon ,  Orna Goren

发明人： Beka Solomon ,  Orna Goren

IPC分类号： A01N63/00

CPC分类号： A61K35/76 ,  C12N2795/14132 ,  C12N2795/14171 ,  Y10S514/879

摘要： Filamentous bacteriophage which does not display an antibody or a non-filamentous bacteriophage antigen on its surface is used to inhibit or treat brain inflammation associated with amyloid deposits and/or involving activated microglia, to inhibit the formation of amyloid deposits, and to disaggregate pre-formed amyloid deposits.

摘要翻译： 在其表面上不显示抗体或非丝状噬菌体抗原的丝状噬菌体用于抑制或治疗与淀粉样蛋白沉积相关的脑炎症和/或涉及活化的小神经胶质细胞，抑制淀粉样蛋白沉积物的形成， 形成淀粉样沉积物。

公开(公告)号：US20090180991A1

公开(公告)日：2009-07-16

申请号：US11815294

申请日：2006-01-31

申请人： Beka Solomon ,  Orna Goren

发明人： Beka Solomon ,  Orna Goren

IPC分类号： A61K35/66 ,  A61P25/28

CPC分类号： A61K35/76 ,  C12N2795/14132 ,  C12N2795/14171 ,  Y10S514/879

摘要： Filamentous bacteriophage which does not display an antibody or a non-filamentous bacteriophage antigen on its surface is used to inhibit or treat brain inflammation associated with amyloid deposits and/or involving activated microglia, to inhibit the formation of amyloid deposits, and to disaggregate pre-formed amyloid deposits.

摘要翻译： 在其表面上不显示抗体或非丝状噬菌体抗原的丝状噬菌体用于抑制或治疗与淀粉样沉积相关的脑炎症和/或涉及活化的小胶质细胞，抑制淀粉样蛋白沉积物的形成， 形成淀粉样沉积物。

公开(公告)号：US09655933B2

公开(公告)日：2017-05-23

申请号：US14384473

申请日：2013-03-15

申请人： RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人： Beka Solomon ,  Eyal Dor-On

IPC分类号： A61K35/76 ,  C12N7/00

CPC分类号： A61K35/76 ,  C12N2795/14132 ,  C12N2795/14171 ,  C12N2810/10 ,  C12N2810/40 ,  Y02A50/473

摘要： The invention relates to a filamentous bacteriophage, carrying bacterial Lipopolysaccharide (LPS) endotoxin on its surface, for use in treating cancer and in inhibiting angiogenesis, and in a different context, for use in promoting angiogenesis in diseases or conditions in which there is insufficient angiogenesis.