公开(公告)号：US10265510B2

公开(公告)日：2019-04-23

申请号：US15503006

申请日：2015-08-12

申请人： CONVERGENT R.N.R LTD

发明人： Zeev Harel ,  Zeev Burshtein ,  Aharon Bar-David ,  Miri Markovich

IPC分类号： A61M37/00 ,  A61N5/10 ,  A61K41/00 ,  A61K9/00

摘要： The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.