公开(公告)号：US11912894B2

公开(公告)日：2024-02-27

申请号：US16696469

申请日：2019-11-26

申请人： CORNELL UNIVERSITY

发明人： Minglin Ma ,  You Yong ,  Mingyu Qiao ,  Qingsheng Liu

IPC分类号： A61L31/14 ,  A61L15/46 ,  A61L29/14 ,  A61L17/00 ,  A61L31/10 ,  A61L29/08 ,  A61L15/60 ,  A61L29/16 ,  A61L17/14 ,  A61L31/16 ,  C09D5/16 ,  B05D3/10 ,  B05D3/06

CPC分类号： C09D5/1625 ,  A61L15/60 ,  A61L17/005 ,  A61L29/085 ,  A61L29/145 ,  A61L29/16 ,  B05D3/067 ,  B05D3/101 ,  B05D3/108 ,  C09D5/1662 ,  C09D5/1687 ,  B05D2201/02 ,  B05D2320/00

摘要： The present application discloses a method of forming a hydrogel-coated substrate, wherein the hydrogel has antifouling and antimicrobial properties. The method comprises applying an aqueous pre-hydrogel solution to a substrate, polymerizing the aqueous pre-hydrogel solution, thereby forming a coated substrate having a conformal hydrogel coating and a non-conformal hydrogel coating, contacting the coated substrate with a swelling agent, and removing the non-conformal hydrogel coating from the coated substrate, thereby leaving the conformal hydrogel coating on the substrate to form the hydrogel-coated substrate. The aqueous pre-hydrogel solution comprises a monomer with antimicrobial activity, a monomer with antifouling activity, and either a polymer, oligomer, or macromer which, when polymerized together, form a hydrogel. Also disclosed is a coated substrate and a hydrogel coating.