公开(公告)号：US20220175978A1

公开(公告)日：2022-06-09

申请号：US17603494

申请日：2020-04-15

Applicant: CORNELL UNIVERSITY

Inventor： Melik Z. Turker ,  Thomas C. Gardinier ,  Ulrich B. Wiesner

IPC: A61K51/12 ,  A61K9/14 ,  A61K49/04 ,  A61K49/00

Abstract: Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for the surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods.

公开(公告)号：US12228553B2

公开(公告)日：2025-02-18

申请号：US17052155

申请日：2019-05-02

Applicant: Cornell University

Inventor： Thomas C. Gardinier ,  Ferdinand F. E. Kohle ,  Joshua A. Hinckley ,  Ulrich B. Wiesner

IPC: G01N30/02 ,  G01N21/64 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

Abstract: The present disclosure provides methods of analyzing and/or purifying inorganic nanoparticles that may be functionalized with one or more dye group. Analyzing and/or purifying the inorganic nanoparticles includes utilizing liquid chromatography, such as, for example, high performance liquid chromatography (HPLC). Methods of the present disclosure may be used to determine the location of one or more dye groups on and/or in the inorganic nanoparticles. The present disclosure also provides methods of making inorganic nanoparticles and compositions of inorganic nanoparticles.

公开(公告)号：US20220153596A1

公开(公告)日：2022-05-19

申请号：US17459562

申请日：2021-08-27

Applicant: CORNELL UNIVERSITY

Inventor： Melik Z. Turker ,  Thomas C. Gardinier ,  Ulrich B. Wiesner ,  Kai Ma

IPC: C01B33/12 ,  A61K51/12 ,  A61K9/51 ,  A61K33/00 ,  A61K49/00

Abstract: Silica nanorings, methods of making silica nanorings, and uses of silica nanorings. The silica nanorings may be PEGylated. The silica nanorings may be surface functionalized, which may be surface selective functionalization, with one or more polyethylene glycol (PEG) group(s), one or more display group(s), one or more functional group(s), or a combination thereof. The silica nanorings may have a size of 5 to 20 nm. The silica nanorings may be made using micelles. The absence or presence of the micelles during PEGylation and/or functionalization allows for surface selective functionalization. The silica nanorings may be used in various diagnostic and/or treatment methods.